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Primary oocytes with cellular senescence features are involved in ovarian aging in mice

ABSTRACT: Primary oocytes with cellular senescence features are involved in ovarian aging in mice

PROVIDER: PRJNA1064403 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27536208.fastq.gz	Fastqsanger.gz
	SRR27536209.fastq.gz	Fastqsanger.gz
	SRR27536210.fastq.gz	Fastqsanger.gz
	SRR27536211.fastq.gz	Fastqsanger.gz
	SRR27536212.fastq.gz	Fastqsanger.gz

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Primary oocytes with cellular senescence features are involved in ovarian aging in mice

Project description:In mammalian females, quiescent primordial follicles serve as the ovarian reserve and sustain normal ovarian function and egg production via folliculogenesis. The loss of primordial follicles causes ovarian aging. Cellular senescence, characterized by cell cycle arrest and production of the senescence-associated secretory phenotype (SASP), is associated with tissue aging. In the present study, we report that some quiescent primary oocytes in primordial follicles become senescent in adult mouse ovaries. The senescent primary oocytes share senescence markers characterized in senescent somatic cells. The senescent primary oocytes were observed in young adult mouse ovaries, remained at approximately 15% of the total primary oocytes during ovarian aging from 6 months to 12 months, and accumulated in aged ovaries. Administration of a senolytic drug ABT263 to 3-month-old mice reduced the percentage of senescent primary oocytes and the transcription of the SASP cytokines in the ovary. In addition, led to increased numbers of primordial and total follicles and a higher rate of oocyte maturation and female fertility. Our study provides experimental evidence that primary oocytes, a germline cell type that is arrested in meiosis, become senescent in adult mouse ovaries and that senescent cell clearance reduced primordial follicle loss and mitigated ovarian aging phenotypes.

2024-04-30 | GSE253194 | GEO

Primary oocytes with cellular senescence features are involved in ovarian aging in mice.

| S-EPMC10802418 | biostudies-literature

Reprogramming of ovarian aging epigenome by resveratrol [methylation]

Project description:Depletion of oocytes and follicles and reduced oocyte quality contribute to age-associated ovarian senescence and infertility. Telomere shortening and altered methylation make two major contributions to general aging. Resveratrol acts as anti-oxidant and Sirt1 activator to alleviate aging including reproductive aging. It remains elusive whether resveratrol can reprogram the aging epigenome. We sought to examine aging ovarian epigenome and the potential effects of resveratrol by combined analysis of telomere length, transcriptome and methylome mainly in oocytes and also in granulosa cells, two major cell types in the ovary.

2021-09-26 | GSE184636 | GEO

Reprogramming of ovarian aging epigenome by resveratrol [RNA-seq]

2021-09-26 | GSE184635 | GEO

Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes

Project description:Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes

| PRJNA1043717 | ENA

Comprehensive molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells

Project description:We aimed to elucidate the molecular features and identify causative factors for PCOS through an integrated, transcriptomic analysis of oocytes and cumulus granulosa cells (GCs) from the same patients with PCOS

2020-09-08 | GSE155489 | GEO

Ovarian senescence, transcriptomic, and epigenomic changes with aging

Project description:Ovarian senescence, transcriptomic, and epigenomic changes with aging

| PRJNA647687 | ENA

Ovarian senescence, transcriptomic, and epigenomic changes with aging

Project description:Ovarian aging is characterized by the progressive depletion of primordial follicle reserve, leading to irregular patterns of ovulation and menopause. The basic mechanisms that underlie the ovarian aging and follicle decline is unknown. We sought to explore the role of cellular senescence and epigenomic mechanisms in ovarian aging. Here, we present the transcriptomic changes observed in the ovaries with age using the age groups 3mo, 6mo, 9mo and 12mo (n=5 per group except for 12mo which has an n=4). The age groups capture timepoints from sexual maturation to reproductive health decline.

2020-07-23 | GSE154890 | GEO

SInsights into molecular features of Venerupis decussata oocytes: a microarray-based study.

Project description:The European clam, Ruditapes decussatus (Linnaeus, 1758), is a bivalve mollusc of the family Veneridae native to the European Atlantic and Mediterranean coastal waters. Its production is exclusively based on natural recruitment, which is subject to high annual fluctuations due to adversely affected by pollution and other environmental factors. In the present study, oocytes from 15 females were collected in Ria de Aveiro (Western coast of Portugal) and microarray analysis was performed in order to investigate gene expression profiles characterizing naturally released oocytes and ovarian oocytes obtained by stripping. Released oocytes were obtained in the context of a study carried out by de Sousa and co-workers (GSE54954: de Sousa et al., 2014, submitted) focusing on expression profiles characterizing oocytes with different quality level. In particular, to compare stripped and spawned oocytes, a total of 10 samples (5 with bad/intermediate hatching rate and 5 with good hatching rate) out of the 25 analyzed in the previous study (GSE54954), and 5 new pools of stripped oocytes, have been analyzed by microarray analyses.

2014-11-05 | GSE58906 | GEO

Increased expression of BubR1 protects against aneuploidy in aging oocytes and extends reproductive lifespan

Project description:Chromosome aneuploidy increases in oocytes with maternal age, and is considered the leading cause for the increased incidence of infertility, miscarriage, and birth defects. Using mRNA-Sequencing of oocytes from 12 month old mouse versus 3 month young mouse, we identified a spindle assembly checkpoint gene, BubR1, whose expression was significantly decreased. We employed a mRNA microinjection based approach to increase BubR1 expression in aging oocytes. We find that increased expression of BubR1 protects against aneuploidy and chromosome misalignment in aging oocytes. After in vitro fertilization, the embryos derived from BubR1 increased expression aging oocytes exhibited chromosome stability as robust as those of the young ones. Furthermore, following embryo transfer, these embryos showed greatly improved developmental competency, with comparable levels of full-term development to those of the young ones. These results indicate that the decline in oocyte quality may be reversible and could lead to treatments that prolong female fertility. Examination of the effect of maternal aging on the mRNA expression in the mature oocytes of the female mice. Naturally ovulated mature oocytes (MII stage) were collected from 6 young (3 month) and 6 aging (12 month) female mice (3 oocytes per mice, 18 oocytes for each group).

2014-05-10 | E-GEOD-57482 | biostudies-arrayexpress

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