Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations

ABSTRACT: BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations

PROVIDER: PRJNA1064982 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations [RNA-seq]

Project description:BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations [RNA-seq]

| PRJNA1064985 | ENA

BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations [Cut&Run]

Project description:BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations [Cut&Run]

| PRJNA1064984 | ENA

BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations [Cut&Run]

Project description:To gain insights into the mechanisms underlying BMI1 activity we assessed binding of BMI1, the PRC1 member RING1B, and the PRC-associated histone marks H3K27me3 and H2AK119ub in SREs and in iSREs.

2025-07-28 | GSE253289 | GEO

BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations [RNA-seq]

Project description:To assess transcriptional consequences of BMI1 overexpression, we performed RNA-seq in SREs and iSREs.

2025-07-28 | GSE253291 | GEO

BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-07-28 | GSE253292 | GEO

Expression data from Bmi1-null common myeloid progenitor (CMP)

Project description:Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf 14. Deletion of both Ink4a and Arf in Bmi1-deficient mice substantially restored the defective self-renewal capacity of HSCs and neural stem cells.

2012-02-08 | GSE31086 | GEO

Transcriptome profiling of Bmi1 silenced-K562 CML cell line

Project description:The Bmi1 Polycomb protein is involved in the epigenetic repressive control of self renewal and survival of cancer initiating cells. In Chronic Myeloid Leukemia (CML), bmi1 expression increases gradually as the disease progresses from a chronic latent phase to a deadly blast crisis. We developped an inducible shRNA system to silence Bmi1 in the human K562 chronic myeloid leukemia (CML) cell line in order to identify new Bmi1-target genes.

2015-05-12 | GSE54262 | GEO

Expression data from Bmi1-null common myeloid progenitor (CMP)

2012-02-08 | E-GEOD-31086 | biostudies-arrayexpress

Expression data from Bmi1-null c-Kit+Sca-1+Lineage marker- (KSL) hematopoietic stem/progenitor cells

2011-02-21 | E-GEOD-19796 | biostudies-arrayexpress

Transcriptome profiling of Bmi1 silenced-K562 CML cell line

2015-05-12 | E-GEOD-54262 | biostudies-arrayexpress