Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-nuclei RNA-Seq profiles from Group 3 and Group 4 medulloblastomas [scRNA-Seq]

ABSTRACT: Single-nuclei RNA-Seq profiles from Group 3 and Group 4 medulloblastomas [scRNA-Seq]

PROVIDER: PRJNA1066283 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Single-nuclei ATAC-Seq profiles from Group 3 and Group 4 medulloblastomas [scATAC-Seq]

Project description:Single-nuclei ATAC-Seq profiles from Group 3 and Group 4 medulloblastomas [scATAC-Seq]

| PRJNA1066320 | ENA

Single-nuclei ATAC-Seq profiles from Group 3 and Group 4 medulloblastomas [scATAC-Seq]

Project description:Frozen Group 3 and Group 4 medulloblastoma samples were processed using Chromium Single Cell Multiome ATAC+Gene or Chromium Single Cell ATAC to obtain single-cell chromatin accessbility profile for individual tumors.

2025-07-09 | GSE253573 | GEO

Single-nuclei RNA-Seq profiles from Group 3 and Group 4 medulloblastomas [scRNA-Seq]

Project description:Frozen Group 3 and Group 4 medulloblastoma samples were processed using Chromium Single Cell Multiome ATAC+Gene or Chromium Single Cell 3'/ATAC to obtain single-cell gene and chromatin accessbility profile for individual tumors.

2025-07-09 | GSE253557 | GEO

Isocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis

Project description:MYC-driven Group-3 medulloblastomas (MB) are malignant pediatric brain cancers without cures. To define actionable metabolic dependencies, we identified upregulationof dihydrolipoyl transacetylase (DLAT), the E2-subunit of pyruvate dehydrogenasecomplex (PDC) in a subset of Group-3 MB with poor prognosis. DLAT was induced by c-MYC and targeting DLAT lowered TCA-cycle metabolism and glutathione synthesis in Group-3 MB cells. We also noted upregulation of isocitrate dehydrogenase 1 (IDH1) in Group-3 MB. Remarkably, genetic and pharmacologic suppression of IDH1 epigenetically reduced c-MYC and downstream DLAT levels. DLAT is a central regulator of cuproptosis, a copper-dependent cell death mechanism induced by the copper ionophore elesclomol. DLAT expression in Group-3 MB cells correlated with increased sensitivity to cuproptosis. Elesclomol was CNS-penetrant and suppressed tumor growth in vivo in Group-3 MB animal models. Our data uncover an IDH1/c-MYC dependent vulnerability that regulates DLAT levels and can be targeted to kill Group-3MB by cuproptosis.

2025-04-10 | GSE278880 | GEO

Isocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis

Project description:Isocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis

| PRJNA1169346 | ENA

Single nuclei RNA-seq profiles from medulloblastoma tumors with extensive nodularity [scRNA-Seq]

Project description:Single nuclei RNA-seq profiles from medulloblastoma tumors with extensive nodularity [scRNA-Seq]

| PRJNA885060 | ENA

Spatial single cell RNA profiles from medulloblastoma Group 3/4 tumors with oncogene aberrations

Project description:Medulloblastomas Group 3/4 are cerebellar tumors with strong inter- and intratumoral heterogeneity. In our research project we focused on specific Group 3/4 tumor cases with somatic aberrations MYC,MYCN and PRDM6 using various single cell techniques.

2025-03-25 | GSE252090 | GEO

Effect of knockdown of Musashi-1 in Group 3/4 medulloblastomas cells

Project description:Effect of knockdown of Musashi-1 in Group 3/4 medulloblastomas cells

| PRJNA941302 | ENA

Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastomas [scRNA+ATAC-seq]

Project description:Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastomas [scRNA+ATAC-seq]

| PRJNA1005997 | ENA

Sonic Hedgehog subgroup medulloblastomas

Project description:Sonic Hedgehog subgroup medulloblastomas

| PRJNA384622 | ENA