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Effect of knockdown of Musashi-1 in Group 3/4 medulloblastomas cells

ABSTRACT: Effect of knockdown of Musashi-1 in Group 3/4 medulloblastomas cells

PROVIDER: PRJNA941302 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23715223_1.fastq.gz	Fastqsanger.gz
	SRR23715223_2.fastq.gz	Fastqsanger.gz
	SRR23715224_1.fastq.gz	Fastqsanger.gz
	SRR23715224_2.fastq.gz	Fastqsanger.gz
	SRR23715225_1.fastq.gz	Fastqsanger.gz

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Effect of knockdown of Musashi-1 in Group 3/4 medulloblastomas cells

Project description:Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a paucity of biomarkers for these subtypes of MBs. In this study, we investigated the clinical significance and biological functions of MSI1 in Grp3/Grp4-MBs. To that, we identified that the MSI1 knockdown sensitized D283 Med cells to cisplatin treatment by enhancing cell apoptosis and modulated cancer-related pathways. The results of the present demonstrate that MSI1 may play a role as biomarker for Grp3/Grp4-MBs. In addition, MSI1 knockdown combined with cisplatin may offer a potential strategy to be further explored in Grp3/Grp4-MBs.

2024-03-03 | GSE226733 | GEO

Musashi-1 is a master regulator of aberrant translation in Group 3 medulloblastoma

Project description:Transcripts regulated by Musashi-1 (MSI1) are explored through shRNA-mediated knockdown of MSI1 in SU_MB002 medulloblastoma cells.

2020-02-01 | GSE126337 | GEO

Musashi-1 is a master regulator of aberrant translation in Group 3 medulloblastoma

Project description:Transcripts bound to Musashi-1 (MSI1) are explored in Group 3 medulloblastoma (G3 MB) and neural stem cells harvested from the cerebellar portion of a embryonal brain

2022-10-28 | GSE126263 | GEO

Isocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis

Project description:MYC-driven Group-3 medulloblastomas (MB) are malignant pediatric brain cancers without cures. To define actionable metabolic dependencies, we identified upregulationof dihydrolipoyl transacetylase (DLAT), the E2-subunit of pyruvate dehydrogenasecomplex (PDC) in a subset of Group-3 MB with poor prognosis. DLAT was induced by c-MYC and targeting DLAT lowered TCA-cycle metabolism and glutathione synthesis in Group-3 MB cells. We also noted upregulation of isocitrate dehydrogenase 1 (IDH1) in Group-3 MB. Remarkably, genetic and pharmacologic suppression of IDH1 epigenetically reduced c-MYC and downstream DLAT levels. DLAT is a central regulator of cuproptosis, a copper-dependent cell death mechanism induced by the copper ionophore elesclomol. DLAT expression in Group-3 MB cells correlated with increased sensitivity to cuproptosis. Elesclomol was CNS-penetrant and suppressed tumor growth in vivo in Group-3 MB animal models. Our data uncover an IDH1/c-MYC dependent vulnerability that regulates DLAT levels and can be targeted to kill Group-3MB by cuproptosis.

2025-04-10 | GSE278880 | GEO

Isocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis

Project description:Isocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis

| PRJNA1169346 | ENA

Microarray analysis of differential gene expression of whole testis extracts from transgenic Musashi-2 and transgenic Musashi-1 over-expression mice

2014-07-12 | GSE59358 | GEO

Single-nuclei RNA-Seq profiles from Group 3 and Group 4 medulloblastomas [scRNA-Seq]

Project description:Single-nuclei RNA-Seq profiles from Group 3 and Group 4 medulloblastomas [scRNA-Seq]

| PRJNA1066283 | ENA

Single-nuclei ATAC-Seq profiles from Group 3 and Group 4 medulloblastomas [scATAC-Seq]

Project description:Single-nuclei ATAC-Seq profiles from Group 3 and Group 4 medulloblastomas [scATAC-Seq]

| PRJNA1066320 | ENA

Microarray analysis of differential gene expression of whole testis extracts from transgenic Musashi-2 and transgenic Musashi-1 over-expression mice

Project description:Analysis of testis-specific over-expression of Musashi-1 and Musashi-2 at gene expression level. The hypothesis tested in the present study was that testis-specific over-expression of Musashi-1/Musashi-2 would result in differential gene expression profiles from the Wildtype control. Results provide important information of the genes affected by Musashi-2 overexpression during spermatogenesis. Total RNA obtained from whole adult testis of transgenic testis-specfic Musashi-1 and Musashi-2 overexpression mice compared to Wildtype (control) littermates. 4 replicates, 16 samples, 2 comparisons: Wt (Musashi-1) vs. TgMsi1 & Wt (Musashi-2) vs. TgMsi2

2014-07-12 | E-GEOD-59358 | biostudies-arrayexpress

Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis

Project description:This SuperSeries is composed of the following subset Series: GSE16432: MSI2 regulates hematopoiesis and accelerates leukemogenesis GSE22773: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible) GSE22774: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK) GSE22775: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines) Refer to individual Series

2010-07-21 | E-GEOD-22778 | biostudies-arrayexpress

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