Project description:Adaptation of Listeria monocytogenes EGD-e to quaternary ammonium compounds
| PRJEB62646 | ENA
Project description:Gdx-Clo 7X Combinatorial Library Screening in Quaternary Ammonium Compounds
| PRJNA1104635 | ENA
Project description:The co-occurrence of ciprofloxacin and dialkyldimethyl ammonium compounds enhanced the proliferation and transfer of three types of resistance genes in nitrification system
| PRJNA990317 | ENA
Project description:Pre-exposure of traditional disinfectants enhances their subsequent combination with quaternary ammonium compounds for resistance enhancing of partial nitrification-anammox system
Project description:Copper-azole based formulations were widely used against fungal decay for preservation of wood timbers. While efficient for wood protection, leaching of both copper and azole within the environment has deleterious impact on soils and surface waters. Moreover, no recycling process is currently available for these wood waste. By taking advantage of the fact that certain fungi have the capacity to cope with these active compounds, we propose that some ligninolytic fungi could be good biocatalysts for detoxifying copper-azole formulations. Using the white-rot fungus Phanerochaete chrysosporium as a model, we demonstrated that the main strategies implemented by this fungus to counteract the antifungal effect of the product, in particular azoles, are the modulation of the lipids and sterols content, the maintenance of DNA integrity, detoxification of azoles by extracellular degradation likely through the Fenton chemistry, biosorption at the cell wall, efflux, and intracellular detoxification by the three-step detoxification pathway. By using comparative transcriptomics between a copper-azole formulation and a copper-quaternary ammonium formulation, we manage to identify genes specifically involved in azole resistance and detoxification within this complex system, opening perspectives for both the identification of key molecular players that could be the targets for developing long-term acquired antifungal resistance mechanisms, and the management of azoles residues by mycoremediation processes.
2025-01-17 | GSE284110 | GEO
Project description:Microbial community succession and resistance genes expression under successive exposure to traditional disinfectants and quaternary ammonium compounds
| PRJNA1080256 | ENA
Project description:Study on antifungal mechanism of quaternary ammonium salt
Project description:The comparison was done in chemostats. Cultures maintained nitrite. The transcritome responses were compared at three ammonium concentrations.
