Project description:recurrent respiratory papillomatosis is a rare benign tumor caused mainly by the infection of the respiratory tract epithelial cells by the human papillamavirus type 6/11.the specific mechanisms underlying the inhibition of the host's innate immune response by HPV remian unclear.For this purpose,we employed single cell RNA sequencing to analyze the states of various immune cells in RRP samples post HPV infection.
Project description:The goal of this study was to determine the differential expression of specific genes within the papilloma tissues themselves and to characterize the array of host genes that might be important in the pathophysiology of recurrent respiratory papillomatosis. Experiment Overall Design: Total RNAs from papillomas (n=12) and adjacent tissues (n=12) were analyzed by Affymetrix microarray, and the matched sets of tissues compared by Genesifter paired t-test to identify differentially expressed genes in papilloma tissues while minimizing variations that are intrinsic to individual patients.
Project description:Juvenile-onset recurrent respiratory papillomatosis (JORRP) is a rare, human papillomavirus (HPV)-driven pediatric disease characterized by recurring papillomas in the respiratory tract. The contribution of dysregulated T-cell immunity to disease severity remains poorly understood. This study included 97 JORRP patients and 124 controls
Project description:The goal of this study was to determine the differential expression of specific genes within the papilloma tissues themselves and to characterize the array of host genes that might be important in the pathophysiology of recurrent respiratory papillomatosis. Keywords: papilloma vs normal adjacent autologous larynx
