Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of STN1 knockdown on gene expression of PDAC cell lines

ABSTRACT: Effect of STN1 knockdown on gene expression of PDAC cell lines

PROVIDER: PRJNA1072721 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27848237_1.fastq.gz	Fastqsanger.gz
	SRR27848237_2.fastq.gz	Fastqsanger.gz
	SRR27848238_1.fastq.gz	Fastqsanger.gz
	SRR27848238_2.fastq.gz	Fastqsanger.gz
	SRR27848239_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Effect of STN1 knockdown on gene expression of PDAC cell lines

Project description:We aimed to elucidate the mechanistic involvement of STN1 in facilitating the metastatic processes of PDAC. Utilizing RNA-seq profiling, we observed a substantial downregulation of the EMT pathway in PANC-1 cells with stable STN1 knockdown

2024-12-31 | GSE254968 | GEO

CD73 knockdown effect in pancreatic cancer cell lines

Project description:CD73 knockdown effect in pancreatic cancer cell lines

| PRJNA480855 | ENA

Microarray analysis of Lynx1 modulation in human PDAC cell lines

Project description:A microarray was performed in order to screen the changes in gene expression following Lynx1 knockdown in 2 human PDAC cell lines Miapaca and BXPC3 and using two specific siRNA to Lynx1

2020-09-01 | GSE152505 | GEO

RNA-seq of human PDAC cell lines PANC-1 and BxPC3 treated with Gemcitabine compared to untreated controls

Project description:Gemcitabine is commonly used for the treatment of PDAC, here we assess the effect of gene expression in human PDAC cell lines.

2023-12-05 | GSE249302 | GEO

STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer

Project description:As pancreatic ductal adenocarcinoma (PDAC) poses a formidable clinical challenge, demanding further exploration of its pathogenesis and drugs targeted for metastasis-the main cause of mortality. Here, we identified STN1, a CST complex member crucial for maintaining telomere lengths and genome stability, as a key factor in promoting PDAC metastasis. Elevated STN1 levels correlate with poor patient survival, with oncogenic protein HOXB7 as an upstream transcription factor regulating STN1. Utilizing multiple PDAC experimental models, we discovered STN1’s role in promoting metastasis by acting as a novel upstream factor in epithelial-mesenchymal transition (EMT). Mechanistically, our proposed model suggests that during transcription, STN1 binds to displaced single-stranded DNA adjacent to the R-loop, recruiting STAT3 to activate ZEB1 transcription independent of its known telomere maintenance function. Notably, STAT3 inhibitors show enhanced efficiency in restraining metastatic potential in STN1-overexpressed PDAC cells, offering promise as a therapeutic avenue for targeting metastasis in STN1-overexpressed PDAC patients facing an unfavorable prognosis.

2025-05-18 | GSE282970 | GEO

H2BG53D mutation in PDAC

Project description:Study was conducted to understand the effect of the cancer associated H2BG53D mutation in PDAC. Using CRISPR/Cas9 Knock-in cell lines expressing FLAG-tagged WT and G53D mutant H2B, we conducted gene expression profilling experiments and studied the effect of the H2BG53D mutation on transcription and PDAC development.

2020-07-01 | GSE134864 | GEO

Effect of Aurora-A knockdown on gene expression in murine CRC cell lines.

Project description:Effect of Aurora-A knockdown on gene expression in murine CRC cell lines.

| PRJNA1036129 | ENA

Effect of FOSL1 and HDAC2 knockdown on gene expression in cancer cell lines

Project description:Effect of FOSL1 and HDAC2 knockdown on gene expression in cancer cell lines

| PRJNA962475 | ENA

Hierarchical clustering of PDAC cell lines

Project description:Hierarchical clustering of pancreatic cancer cell lines based on differentially regulated genes between mesenchymal and epithelial PDAC cells derived from primary tumours and metastases from KrasG12D-driven mouse models of pancreatic cancer.

2022-11-19 | E-MTAB-8173 | biostudies-arrayexpress

Genome wide gene expression profile of pancreatic ductal adenocarcinoma (PDAC) cells after knock down of focal adhesion kinase (FAK).

Project description:In our experiments, we showed that FAK regulates PDAC clonogenicity and selfrenewal. In order to evaluate the impact of FAK knockdown on the transcriptomes of PDAC , we knocked down FAK in two PDAC cell lines and compared the gene expression signatures with the cancer stem cell (CSC)associated gene signatures by GSEA analysis. CCS related gene profile was inversely related with FAK-knockdown gene signature.

2017-04-20 | GSE97488 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data