Project description:To find genes deregulated in the pathogenisis of T-cells in Atm deficient mice, we performed expression profiling of Atm deficient thymic lymphomas, wildtype thymi and Atm deficient thymi without macroscopic enlargement, representing an intermediate stage in the process of tumorigenisis. Keywords: genetic modification, disease state analysis
Project description:CD4 and CD8 murine T-cells from Atm-deficient mice show marked transcriptional changes compared to T-cells from wt mice and respond differently to the transplantation of B-cell lymphoma
