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Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor

ABSTRACT: Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor

PROVIDER: PRJNA1075437 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27941100.fastq.gz	Fastqsanger.gz
	SRR27941101.fastq.gz	Fastqsanger.gz
	SRR27941102.fastq.gz	Fastqsanger.gz
	SRR27941103.fastq.gz	Fastqsanger.gz
	SRR27941104.fastq.gz	Fastqsanger.gz

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Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor [RNAseq_KI_tumor]

Project description:Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor [RNAseq_KI_tumor]

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Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor

Project description:Identifying patients at risk for metastatic relapse is a critical need in oncology. We identified a common missense germline variant in PCSK9 that associates with reduced breast cancer survival outcomes in multiple cohorts. Genetic modeling of this gain-of-function single nucleotide variant in mice revealed that it causally promoted breast cancer metastasis. Conversely, host PCSK9 deletion reduced metastatic colonization in multiple breast cancer models. Host PCSK9 promoted metastatic initiation events in lung and increased proliferative competence by targeting tumoral LRP1 receptors which repress metastasis-promoting genes. Antibody-mediated therapeutic inhibition of PCSK9 suppressed breast cancer metastasis in multiple models. This variant stratified women in a large Swedish early-stage breast cancer cohort into those with 98% versus 78% distant-metastasis-free interval at 15 years after diagnosis. Our findings reveal that a commonly inherited genetic alteration predicts breast cancer survival and governs breast cancer metastasis—uncovering a hereditary basis underlying a prevalent cause of mortality.

2024-12-09 | GSE255560 | GEO

Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor [RNAseq_KI_tumor]

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Effect of recombinant PCSK9 treatment on the gene expression of EO771 cells

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Effect of recombinant PCSK9 treatment on the gene expression of EO771 cells

Project description:Effect of recombinant PCSK9 treatment on the gene expression of EO771 cells

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Effect of Lrp1 knockdown on the gene expression of EO771 cells

2024-12-09 | GSE255559 | GEO

Comparing the transcriptome expression differences between breast cancer cells EO771-tdT-Parental and EO771-tdT-LM2 using high-throughput sequencing.

Project description:The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, limiting development of effective therapies. Here we show that BCCs in mice can invade the LM by abluminal migration along blood vessels that connect vertebral/calvarial bone marrow and meninges, bypassing the blood-brain barrier. To screen for signaling pathways in EO-LM2 cells that could support their survival or proliferation in the meningeal niche, we performed RNA-seq analysis of EO771-tdT-Parental and EO771-tdT-LM2 to compare their transcriptome expression differences.

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Transcription profiling of human HepG2 cells expressing gain-of-function mutant D374Y-PCSK9

Project description:We have transfected Hep2G cells with the gain-of-function mutant D374Y-PCSK9.

2008-01-30 | E-MEXP-1235 | biostudies-arrayexpress

A common human PCSK9 germline variant drives breast cancer metastasis via the LRP1 receptor

Project description:Identifying patients at risk for metastatic relapse is a critical need in oncology. We identified a common missense germline variant in PCSK9 (rs562556) that associates with reduced breast cancer survival outcomes in multiple cohorts. Genetic modeling of this gain-of-function single nucleotide variant in mice revealed that it causally promoted breast cancer metastasis. Conversely, host PCSK9 deletion reduced metastatic colonization in multiple breast cancer models. Host PCSK9 promoted metastatic initiation events in lung and increased proliferative competence by targeting tumoral LRP1 receptors which repress metastasis-promoting genes. Antibody-mediated therapeutic inhibition of PCSK9 suppressed breast cancer metastasis in multiple models. rs562556 stratified women in a large Swedish early-stage breast cancer cohort into those with 98% versus 78% distant-metastasis-free interval at 15 years after diagnosis. Our findings reveal that a commonly inherited genetic alteration predicts breast cancer survival and governs breast cancer metastasis—uncovering a hereditary basis underlying a prevalent cause of mortality.

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