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Effect of recombinant PCSK9 treatment on the gene expression of EO771 cells

ABSTRACT: Effect of recombinant PCSK9 treatment on the gene expression of EO771 cells

PROVIDER: PRJNA1075439 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27941074.fastq.gz	Fastqsanger.gz
	SRR27941075.fastq.gz	Fastqsanger.gz
	SRR27941076.fastq.gz	Fastqsanger.gz
	SRR27941077.fastq.gz	Fastqsanger.gz
	SRR27941078.fastq.gz	Fastqsanger.gz

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Effect of recombinant PCSK9 treatment on the gene expression of EO771 cells

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Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor

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Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor [RNAseq_KI_tumor]

Project description:Effect of host PCSK9 treatment on the gene expression of EO771 primary tumor [RNAseq_KI_tumor]

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Effect of Lrp1 knockdown on the gene expression of EO771 cells

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RNA-seq of mouse EO771 triple-negative breast cancer model with stemness inhibitors: salinomycin, SB-431542, JIB-04, napabucasin, and their quadruple combination against an untreated control

Project description:We conducted an in vivo study of stemness inhibitors using the EO771 triple-negative breast cancer mouse model. Ten days after subcutaneous injection of 1 million of EO771 cells into 8-12 week C57BL/6 female mice right flank, tumors reached around 100-200 mm³. Each treatment group (n=2-3 per group) received three doses of stemness inhibitors (every 3 days) in monotherapy (A - salinomycin, B - SB-431542, C - JIB-04, D - napabucasin) or combination therapy (ABCD). Control mice were left untreated. Tumors were harvested one day after the last treatment and subjected to bulk RNA-seq. This study aims to identify if treatment with stemness inhibitors affected the immune tumor microenvironment in this model.

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Comparing the transcriptome expression differences between breast cancer cells EO771-tdT-Parental and EO771-tdT-LM2 using high-throughput sequencing.

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Effect of Lrp1 knockdown on the gene expression of EO771 cells

Project description:Effect of Lrp1 knockdown on the gene expression of EO771 cells

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