Project description:Constitutive Pla2g4e knockout mice exhibited significant behavioral alterations, particularly in memory function, different brain lipid composition, and decreased levels of cortical synaptic plasticity markers compared to wild-type counterparts.We performed gene expression profiling analysis os neurons lacking PLA2G4E to study the function of this enzyme in synaptic transmission.

2025-07-08 | GSE259324 | GEO

PLA2G4E Orchestrates optimal Synapse Development and Neuronal Maturation [KO_Pla2g4e]

Project description:Constitutive Pla2g4e knockout mice exhibited significant behavioral alterations, particularly in memory function, different brain lipid composition, and decreased levels of cortical synaptic plasticity markers compared to wild-type counterparts.We performed gene expression profiling analysis animals lacking PLA2G4E to study the function of this enzyme in memory function.

2025-07-08 | GSE259323 | GEO

Neuronal extracellular vesicles mediate BDNF-dependent dendritogenesis and synapse maturation via microRNAs

Project description:Neuronal extracellular vesicles mediate BDNF-dependent dendritogenesis and synapse maturation via microRNAs

| PRJNA767079 | ENA

Neuronal extracellular vesicles mediate BDNF-dependent dendritogenesis and synapse maturation via microRNAs

Project description:Extracellular vesicles (EVs) are emerging as novel mediators of cellular communication, in part via the delivery of their contents including microRNAs; small non-coding RNAs that regulate gene expression and are crucial for neuronal circuit formation and function. Whether microRNAs are transferred between differentiated neurons is so far unknown. Moreover, the physiological role of EVs in inter-neuronal signaling is largely elusive. We observed that EVs derived from brain-derived neurotrophic factor (BDNF)-treated neurons induced dendrite complexity, synapse maturation and neuronal firing in recipient hippocampal neurons. This was dependent on the activity of three microRNAs, miR-132-5p, miR-218-5p and miR-690, that were specifically up-regulated in BDNF-induced EVs. Transcriptomic analysis further showed the differential expression of genes related to synaptogenesis in BDNF-EV-treated neurons, many of which are conserved targets of these miRNAs. Overall, this work demonstrates a novel mechanism of inter-neuronal communication, which may be highly relevant in neurological disorders characterized by aberrant BDNF signaling.

2023-12-05 | GSE184945 | GEO

STING1 orchestrates the injurious neuronal stress response

Project description:STING1 orchestrates the injurious neuronal stress response

| PRJNA1047641 | ENA

Myeloid C3 causes neuronal injury prior to synapse loss

Project description:Myeloid C3 causes neuronal injury prior to synapse loss

| PRJNA1084770 | ENA

Microglial remodeling of the extracellular matrix promotes synapse plasticity [Neuronal nuclei]

Project description:Microglial remodeling of the extracellular matrix promotes synapse plasticity [Neuronal nuclei]

| PRJNA633364 | ENA