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Human iPSC-derived cell grafts promote functional recovery by molecular interaction with stroke-injured brain

ABSTRACT: Human iPSC-derived cell grafts promote functional recovery by molecular interaction with stroke-injured brain

PROVIDER: PRJNA1081470 | ENA |

REPOSITORIES: ENA

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Human iPSC-derived cell grafts promote functional recovery by molecular interaction with stroke-injured brain

Project description:IPSC-NPC were transplanted in a mouse model of stroke. To dissect the molecular graft composition and identify graft-host interactions, single nucleus profiling of the cell transplants and host stroke tissue was performed. We identified graft differentiation preferentially towards GABAergic cells with remaining cells acquiring glutamatergic neuron, astrocyte, and NPC-like phenotypes. Interaction between graft and host transcriptome indicated that GABAergic cell grafts were primarily involved in graft-host communication through the regeneration-associated NRXN, NRG, NCAM and SLIT signalling pathways

2025-08-06 | GSE259430 | GEO

CREB Controls Cortical Circuit Plasticity and Functional Recovery after Stroke

Project description:Treatments that stimulate neuronal excitability enhance motor performance after stroke.cAMP-response-element binding protein (CREB) is a transcription factor that plays a key rolein neuronal excitability. Increasing the levels of CREB with a viral vector in a small pool ofmotor neurons enhances motor recovery after stroke, while blocking CREB signaling preventsstroke recovery. Silencing CREB-transfected neurons in the peri-infarct region with thehM4di-DREADD blocks motor recovery. Reversing this inhibition allows recovery to continue,demonstrating that it is possible to turn off and on stroke recovery by manipulating theactivity of CREB-transfected neurons. CREB transfection enhances re-mapping of injuredsomatosensory and motor circuits, and induces the formation of new connections withinthese circuits. CREB is a central molecular node in the circuit responses after stroke that leadto recovery from motor deficits.

2018-06-08 | GSE115527 | GEO

microRNAs involved in regulating embolic stroke recovery following spontaneous reperfusion [miRNA]

Project description:To date, miRNA expression studies on cerebral ischemia in both human and animal models have focused mainly on acute phase of ischemic stroke. In this study, we present the roles played by microRNAs in the spontaneous recovery phases in cerebral ischemia using rodent stroke models. In this study presented here, Middle Cerebral Artery Occlusion stroke model was established by using embolus and the brain samples of stroke model were harvested at 0hrs, 3hrs, 6hrs, 12hrs, 24hrs, 48hrs, 72hrs, 120hrs and 168hrs. RNAs were extracted from these samples and microRNA array and mRNA array were performed.

2013-12-09 | E-GEOD-46266 | biostudies-arrayexpress

microRNAs involved in regulating embolic stroke recovery following spontaneous reperfusion [mRNA]

Project description:To date, miRNA and mRNA expression studies on cerebral ischemia in both human and animal models have focused mainly on acute phase of ischemic stroke. In this study, we present the roles played by microRNAs in the spontaneous recovery phases in cerebral ischemia using rodent stroke models. In this study presented here, Middle Cerebral Artery Occlusion stroke model was established by using embolus and the brain samples of stroke model were harvestd at 0hrs, 3hrs, 6hrs, 12hrs, 24hrs, 48hrs, 72hrs, 120hrs and 168hrs. RNAs were extracted from these samples and microRNA array and mRNA array were performed.

2013-12-09 | E-GEOD-46267 | biostudies-arrayexpress

Activity-dependent Transcriptional Programs in Memory Regulate Motor Recovery after Stroke

Project description:Stroke causes death of brain tissue leading to long-term deficits. Behavioral evidence from neurorehabilitative therapies suggest learning-induced neuroplasticity can lead to beneficial outcomes. However, molecular and cellular mechanisms that link learning and stroke recovery are unknown. We show that in mouse models of stroke, with enhanced recovery of function from genetic perturbations of learning and memory genes, express activity-dependent transcriptional programs that are normally active during formation or storage of new memories. The expression of neuronal activity-dependent genes are predictive of recovery and occupy a molecular latent space unique to motor recovery. With motor recovery, networks of activity-dependent genes are co-expressed with their transcription factor targets forming gene regulatory networks that support activity-dependent transcription, that are normally diminished after stroke. Neuronal activity-dependent changes at the circuit level are influenced by interactions with microglia. At the molecular level, we show that enrichment of activity-dependent programs in neurons lead to transcriptional changes in microglia where they differentially interact to support intercellular signaling pathways for axon guidance, growth and synaptogenesis. Together, these studies identify activity-dependent transcriptional programs as a fundamental mechanism for neural repair post-stroke.

2024-06-25 | GSE270766 | GEO

Trained immunity induced by high salt diet impedes stroke recovery

Project description:High salt diet-induced functional adaptions in bone marrow progenitor cells, which subsequently reduced monocyte-derived macrophage reparative phenotype and impeded stroke recovery

2023-08-29 | GSE214728 | GEO

Short-chain fatty acids improve post-stroke recovery via immunological mechanisms.

Project description:This transcriptomic study investigates the effect of therapeutic short-chain fatty acids (SCFA) administration on post-stroke recovery.

2020-01-01 | GSE131788 | GEO

microRNAs involved in regulating embolic stroke recovery following spontaneous reperfusion [miRNA]

2013-12-09 | GSE46266 | GEO

microRNAs involved in regulating embolic stroke recovery following spontaneous reperfusion [mRNA]

2013-12-09 | GSE46267 | GEO

Exome sequencing of stroke cases with good or bad recovery three months after stroke

Project description:With the aim to identify rare genetic variation involved in stroke recovery, this is a pilot study on extreme phenotypes of good and bad recovery. Exome sequencing was performed on 41 and 49 samples in the bad and good recovery subset, respectively. Rare Variant association Analysis was performed on the exome sequencing results.

| EGAS00001003463 | EGA

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