Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell RNA sequencing for CD34 lineage cells from normal and Angiotensin Ⅱ-induced abdominal aneurysmal aorta

ABSTRACT: Single cell RNA sequencing for CD34 lineage cells from normal and Angiotensin Ⅱ-induced abdominal aneurysmal aorta

PROVIDER: PRJNA1083911 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28227755_1.fastq.gz	Fastqsanger.gz
	SRR28227755_2.fastq.gz	Fastqsanger.gz
	SRR28227756_1.fastq.gz	Fastqsanger.gz
	SRR28227756_2.fastq.gz	Fastqsanger.gz
	SRR28227757_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 56

Similar Datasets

Single cell RNA sequencing for normal and Angiotensin Ⅱ-induced thoracic and abdominal aneurysmal aorta

Project description:Single cell RNA sequencing for normal and Angiotensin Ⅱ-induced thoracic and abdominal aneurysmal aorta

| PRJNA916216 | ENA

Lysyl hydroxylase 1 deficiency exacerbates the alterations of gene transcriptional profile of abdominal aorta in angiotensin II induced abdominal aortic aneurysm

Project description:Lysyl hydroxylase 1 (LH1) plays an important role in hydroxylation of lysyl residuel in Xaa-Lys-Gly. The hydroxylysine residues serve as sites of attachment for carbohydrate units which are essential for the formation of intra- and intermolecular collagen crosslinks. To gain mechanistic insights into the effects of LH1 deficiency on abdominal aortic aneurysm (AAA) formation, a whole transcriptomic analysis of abdominal aorta were performed using RNA-seq. The abdominal aorta of mice for RNA-seq were acquired at day 14 after angiotensin II infusion in order to provide the mechanistic or causal evidence of a direct participatory role of LH1 to the effects of AAA.

2021-08-15 | GSE175683 | GEO

Single cell RNA sequencing for CD34 lineage cells from normal and Angiotensin Ⅱ-induced abdominal aneurysmal aorta

Project description:The development of aneurysm is involved in imbalance between connective tissue repair and degradation. CD34+ cells are a heterogeneous population with stem/progenitor cell properties. However, the role of CD34+ cells in abdominal aortic aneurysms/dissections (AAAs) is unknown. We aimed to uncover the exact role and potential mechanism of CD34+ cells in the development of AAAs.

2025-02-26 | GSE260887 | GEO

MERSCOPE profiling of non-aneurysmal and aneurysmal human ascending aorta

Project description:MERSCOPE profiling of non-aneurysmal and aneurysmal human ascending aorta

| PRJNA1010377 | ENA

RNA-sequencing of abdominal aortic aneurysm (AAA) and control abdominal aorta tissues

Project description:Abdominal aortic aneurysm (AAA) is a permanent segmental dilatation of the abdominal aorta, contributing to a high mortality once rupture. We performed RNA-sequencing analysis of abdominal aorta tissues from 14 participants, including seven patients with AAA and seven control individuals.

2023-12-07 | GSE183464 | GEO

Comparison of infrarenal and suprarenal sections of mouse ApoE-/- abdominal aorta

Project description:The ApoE -/- mice model of abdominal aortic aneurysm (AAA) involves introducing Angiotensin II subcutaneously to 14 week old male mice for 4 weeks by osmotic pump. A significant number of mice will develop aneurysm-like dilations in the suprarenal section of the abdominal aorta (SRA) that have a number of similarities to the human condition and make this a useful model of AAA. The mouse infrarenal aorta is very resistant to aneurysm formation while in humans AAA predominately occurs in the infrarenal section of the aorta (IRA). There have been a number of theories proposed to explain the site selctivity of aneurysm formation in AAA and this mice model. This study was designed to ascertain differences between SRA and IRA that may explain this site selectivity. Keywords: tissue type comparison

2010-05-12 | GSE7006 | GEO

Unraveling CD4+ T Cell Diversity in Abdominal Aortic Aneurysms

Project description:We conducted single-cell RNA sequencing (scRNA-seq) on CD4+ T cells of the aneurysmal aorta and the corresponding splenic cells, in order to unveil the diversity of CD4+ T Cell in Abdominal Aortic Aneurysms.

2024-05-06 | GSE253247 | GEO

Expression data from the abdominal aorta and abdominal aortic aneurysm

Project description:Global gene expression information that can be used to identify pathways involved in the pathophysiology of disease. We used microarrays to identify which genes are expressed in either the abdominal aorta (control) or in abdominal aortic aneurysms (case), and also which genes may be differential between the two tissue states. Keywords: Characterization of expression in both diseased and non-diseased abdominal aortas.

2007-07-26 | GSE7084 | GEO

Single cell RNA sequencing for normal and Angiotensin Ⅱ-induced thoracic and abdominal aneurysmal aorta

Project description:Aortic aneurysm is a life-threatening disease resulted from progressive dilatation of the aorta and weakness of the blood vessel walls . While the two diseases share several etiological similarities, there are also significant differences in population prevalence rate, genetic patterns and susceptibility genes. However, both TAAs and AAAs are complex, multifactorial and highly heterogeneous diseases, which greatly restricts our better knowledge of the two diseases. An improved knowledge of the cellular mechanism networks that trigger the development and succeeding expansion of aneurysms is critical to discovering innovative therapeutic targets.

2023-02-01 | GSE221789 | GEO

Transcription profiling of mouse suprarenal aorta from ApoE knock-outs treated with angiotensin II or saline to study developing abdominal aortic aneurysm (AAA)

Project description:Transcriptional profiling of suprarenal aorta from ApoE-/- mice (12-14 weeks old, C57BL/6J background) treated by subcutaneous pump with angiotensin II or saline for 7d, 14d and 28d. Includes Ang II-treated samples at 7d found to have dissected aneurysms. Goal was to examine gene expression in developing AAA in this model over time. Experiment Overall Design: Two condition experiment, one suprarenal aorta per array. Saline vs. angiotensin II at 3 time points, with inclusion of 3 Ang II-treated dissected. Total 35 arrays: 6 saline 7d, 6 saline 14d, 5 saline 28d, 4 Ang II 7d, 5 Ang II 14d, 6 Ang II 28d, 3 Ang II-dissected 7d.

2009-10-09 | E-GEOD-17901 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data