Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genomic copy number alterations as predictive markers in breast cancer

ABSTRACT: Genomic copy number alterations as predictive markers in breast cancer

PROVIDER: PRJNA108393 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Genomic copy number alterations as predictive markers in breast cancer

Project description:This SuperSeries is composed of the following subset Series: GSE10128: Genomic copy number alterations as predictive markers of systemic recurrence in breast cancer GSE10129: Genomic copy number alterations as predictive markers of neoadjuvant chemotherapy response in breast cancer Refer to individual Series

2010-05-27 | E-GEOD-10181 | biostudies-arrayexpress

Copy number alterations in osteosarcoma CTC

Project description:Copy number alterations in osteosarcoma CTC

| PRJEB107060 | ENA

Retrograde signalling mediates cellular adaptation to mitochondrial DNA copy number alterations

Project description:Eukaryotic cells maintain multiple copies of the mitochondrial genome, which is essential for cellular metabolism. Accordingly, alterations in the mitochondrial DNA (mtDNA) copy number are associated with severe human diseases and ageing. However, the mechanisms through which cells regulate mtDNA copy number and the cellular consequences of altered copy number remain poorly understood. Here, using budding yeast as a model, we show that mtDNA copy number is determined by the amount of three limiting factors, Mip1, Abf2, and Rim1. By synthetically tuning the concentrations of only these three proteins, we can modulate mtDNA dosage inside the cell. This revealed that cells are surprisingly robust to mtDNA copy number alterations, with increased copy numbers even accelerating cell growth. Our findings suggest that this robustness is due to protein dosage compensation and independent regulation of mitochondrial morphology. Mechanistically, we identified a critical role of the retrograde signalling pathway for this adaptation. We show that signalling from mitochondria to the nucleus is upregulated in cells with higher mtDNA copy number, and disruption of this regulation diminishes their faster growth. Taken together, our work reveals regulatory principles that allow cells to adapt to mtDNA copy number alterations.

2026-07-26 | PXD081636 | Pride

Genomic copy number alterations as predictive markers of systemic recurrence in breast cancer

2008-01-17 | GSE10128 | GEO

Genomic copy number alterations as predictive markers of neoadjuvant chemotherapy response in breast cancer

2008-01-17 | GSE10129 | GEO

Genomic copy number alterations as predictive markers of systemic recurrence in breast cancer

Project description:Array CGH containing 4,044 human bacterial artificial chromosome clones was used to assess copy number changes in 31 pairs of clinicopathologically well matched recurred / nonrecurred breast cancer tissues. Array CGH containing 4,044 human bacterial artificial chromosome clones was used to assess copy number changes in 31 pairs of clinicopathologically well matched recurred / nonrecurred breast cancer tissues.

2010-05-26 | E-GEOD-10128 | biostudies-arrayexpress

Genomic copy number alterations as predictive markers of neoadjuvant chemotherapy response in breast cancer

Project description:Array CGH containing 4,044 human bacterial artificial chromosome clones was used to assess different copy number changes between chemotherapy responsive and non-resposive breast cancer tissues. Array CGH containing 4,044 human bacterial artificial chromosome clones was used to assess different copy number changes between chemotherapy responsive and non-resposive breast cancer tissues.

2010-05-26 | E-GEOD-10129 | biostudies-arrayexpress

DNA copy number alterations in radiation-induced rat renal carcinomas

Project description:DNA copy number alterations in radiation-induced rat renal carcinomas

| PRJNA673183 | ENA

DNA copy number alterations in radiation-induced rat mammary carcinomas

Project description:DNA copy number alterations in radiation-induced rat mammary carcinomas

| PRJNA673421 | ENA

Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

Project description:Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

| PRJNA75573 | ENA