Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Murine oral candidiasis (IL-17RA/IL-22R knockout mice)

PROVIDER: PRJNA1094974 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28517712.fastq.gz	Fastqsanger.gz
	SRR28517713.fastq.gz	Fastqsanger.gz
	SRR28517714.fastq.gz	Fastqsanger.gz
	SRR28517715.fastq.gz	Fastqsanger.gz
	SRR28517716.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

E-MTAB-4167

Project description:Transcription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis

2016-01-05 | E-MTAB-4167 | ExpressionAtlas

Gene expression analysis in the kidney following disseminated candididiasis

Project description:Comparative analysis of renal gene expression between wild type and mice deficient in IL-17 receptor signaling following disseminated candidiasis. The hypothesis to be tested in the present study was that there should be a differential renal gene expresion in the absence of IL-17 receptor signaling following disseminated candidiasis. Wild type and IL-17RA-/- mice were systemically infected with Candida albicans and 48 hour post infection renal gene expression was analyzed.

2016-10-18 | GSE88800 | GEO

Project description:Microbiome diversity of IL-17RA knockout mice

| PRJNA698550 | ENA

Role of IL-17RA in the development of parasite-specific cytotoxic responses during Trypanosoma cruzi infection

Project description:IL-17RA knockout mice presented increased tissue parasitism during T. cruzi infection that correlated with a reduced frequency of parasite-specific CD8+ T cells. Parasite-specific CD8+ T cells from KO mice showed similar proliferation rate but increased mortality and an exhausted phenotype when compared to WT counterparts. We hypothesize that during T. cruzi infection, IL-17RA signaling in CD8+ T cells is required for the regulation of a transcriptional program that prevents accelerated mortality and exhaustion and sustain the development of robust cytotoxic response required for efficient parasite control.

2020-01-31 | E-MTAB-2438 | biostudies-arrayexpress

Mus musculus

Project description:IL-17RA signaling in oral epithelium is necessary and sufficient for protection against oropharyngeal candidiasis

| PRJNA322012 | ENA

E-GEOD-30495

Project description:Gene expression profile of PPARalpha knockout and wild type mice after a single oral dose of different synthetic triglycerides

2015-09-21 | E-GEOD-30495 | ExpressionAtlas

Gene expression in IL-17RA-deficient and wild-type mice following Giardia muris infection

Project description:To elucidate IL-17A-dependent immune mechanims involved in regulating host defense, we employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential of regulating protective immunity that failed to be upregulated in the absence of IL-17RA signaling. Whole small intestine tissue collected from IL-17RA-deficient and C57BL/6 (wild-type) mice was collected 2 weeks after Giardia muris infection and from uninfected controls. Expression levels of several genes that may have anti-parasitic potential (Defb1, Retnlb, Saa1, Saa2) and may be involved in parasite clearance were, on average, lower or unchanged in IL-17RA deficient compared to wild-type mice after infection. Two weeks after Giardia muris challenge, total RNA was extracted and analyzed from tissue of the small intestines of infected IL-17RA-deficient and wild-type mice, and compared to uninfected controls. Each sample contained equal amounts of total RNA from 6 female mice which were pooled and used in the experiment.

2015-05-15 | E-GEOD-68868 | biostudies-arrayexpress

Aberrant type 1 immunity drives mucosal fungal infection susceptibility

Project description:The objective of this study was to understand the impact of autoimmune regulator (AIRE) on immunity against oral Candida albicans infection. Previous work indicated that autoantibodies against IL-17 and IL-22 may contribute to host susceptibility; however, there is not a 100% correlation between autoantibodies and mucosal candidiasis in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) patients, indicating that other pathways may be affected. Using a mouse model that very closely mimics what is seen in APECED patients, oral epithelial cells were sorted and RNA extracted from them to perform RNA-seq analysis to determine what other pathways may be involved. These data show that the type II interferon pathway is highly upregulated in Aire-deficient mice, while the IL-17R pathway is intact.

2021-08-11 | GSE133603 | GEO

Gene expression in IL-17RA-deficient and wild-type mice following Giardia muris infection

2015-05-15 | GSE68868 | GEO

E-GEOD-19272

Project description:Genome-wide comparison between IL-17 and combined TNF-alpha/ IL-17 induced genes in primary murine hepatocytes

2015-09-16 | E-GEOD-19272 | ExpressionAtlas