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Spatial Coding Dysfunction & Network Instability in the Aging Medial Entorhinal Cortex

ABSTRACT: Spatial Coding Dysfunction & Network Instability in the Aging Medial Entorhinal Cortex

PROVIDER: PRJNA1096744 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28572738_1.fastq.gz	Fastqsanger.gz
	SRR28572738_2.fastq.gz	Fastqsanger.gz
	SRR28572739_1.fastq.gz	Fastqsanger.gz
	SRR28572739_2.fastq.gz	Fastqsanger.gz
	SRR28572740_1.fastq.gz	Fastqsanger.gz

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Spatial Coding Dysfunction & Network Instability in the Aging Medial Entorhinal Cortex

Project description:Spatial Coding Dysfunction & Network Instability in the Aging Medial Entorhinal Cortex

| PRJNA1185693 | ENA

Spatial Coding Dysfunction & Network Instability in the Aging Medial Entorhinal Cortex

Project description:Across species, spatial memory declines with age, possibly reflecting altered hippocampal and medial entorhinal cortex (MEC) function. However, the integrity of cellular and network-level spatial coding in aged MEC is unknown. Here, we leveraged electrophysiology to assess MEC function in young, middle-aged, and aged mice navigating virtual environments. In aged grid cells, we observed impaired stabilization of context-specific spatial firing, correlated with spatial memory deficits. Additionally, aged grid networks shifted firing patterns often but with poor alignment to context changes. Aged spatial firing was also unstable in an unchanging environment. In these same mice, we identified 462 genes differentially expressed with age in MEC, 61 of which had expression correlated with spatial firing stability. These genes were interneuron-specific and related to synaptic transmission. Together, these findings identify coordinated transcriptomic, cellular, and network changes in MEC implicated in impaired spatial memory in aging.

2025-07-09 | GSE281777 | GEO

Spatial Coding Dysfunction & Network Instability in the Aging Medial Entorhinal Cortex

Project description:Across species, spatial memory declines with age, possibly reflecting altered hippocampal and medial entorhinal cortex (MEC) function. However, the integrity of cellular and network-level spatial coding in aged MEC is unknown. Here, we leveraged in vivo electrophysiology to assess MEC function in young, middle-aged, and aged mice navigating virtual environments. In aged grid cells, we observed impaired stabilization of context-specific spatial firing, correlated with spatial memory deficits. Additionally, aged grid networks shifted firing patterns often but with poor alignment to context changes. Aged spatial firing was also unstable in an unchanging environment. In these same mice, we identified 458 genes differentially expressed with age in MEC, 61 of which had expression correlated with spatial firing stability. These genes were enriched among interneurons and related to synaptic transmission. Together, these findings identify coordinated transcriptomic, cellular, and network changes in MEC implicated in impaired spatial memory in aging.

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Very deep small RNA sequencing of whole rat medial entorhinal cortex

Project description:We performed very deep small RNA sequencing on one sample of medial entorhinal cortex of a Long Evans rat aged P23 to see which small RNAs could be detected in this brain area.

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Project description:To examine how miRNAs differ between medial entorhinal cortex layers during postnatal development, we analyzed the miRNA expression in layer II and the deep layers (III-VI) at postnatal ages P2, P9, P23 and P45 in wildtype Long Evans rats. The expression of the two most significantly differentially expressed miRNAs were validated by in situ hybridization.

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