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External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle II

ABSTRACT: External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle II

PROVIDER: PRJNA1097580 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28590609_1.fastq.gz	Fastqsanger.gz
	SRR28590609_2.fastq.gz	Fastqsanger.gz
	SRR28590610_1.fastq.gz	Fastqsanger.gz
	SRR28590610_2.fastq.gz	Fastqsanger.gz
	SRR28590611_1.fastq.gz	Fastqsanger.gz

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External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle II

Project description:Exosomes are nanosized extracellular vesicles which have been recently demonstrated as promising agents for tissue repair/regeneration by inducing and guiding appropriate immune responses in dystrophic pathologies. Unfortunately, the accurate manipulation of exosomes by controlling their biodistribution still poses significant challenges. Here we overcome this limitation by developing an externally controlled delivery system for primed ANXA1 myo-exosomes (Exomyo). Effective nanocarriers are realized by immobilizing the Exomyo onto ferromagnetic nanotubes (NT-MAG) to achieve a controlled delivery and localization of Exomyo into skeletal muscles by an applied external magnetic field. Quantitative muscle-level analyses revealed that macrophages dominate the uptake of Exomyo from NT-MAG in vivo, to synergistically promote beneficial muscle responses in a murine animal model of Duchenne Muscular Dystrophy (DMD) thanks to the successful localization of therapeutic Exomyo upon systemic injection. These findings provide valuable insights into the development of exosome-based therapies for muscle diseases and in general highlight the formulation of effective functional nanocarriers aimed at optimizing exosome biodistribution.

2024-07-23 | GSE263456 | GEO

External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle I

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External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle

Project description:External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle

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External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle I

Project description:External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle I

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External magnetic-field driven delivery of exosomes modulates immune and metabolic changes of dystrophic muscle

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-23 | GSE263457 | GEO

Effects of magnetite nanoparticles and static magnetic field on neural differentiation of pluripotent stem cells

Project description:Neural proliferation and differentiation fates of pluripotent stem cells are influenced by external natural forces. Despite the presence of biogenic magnetite nanoparticles in the central nervous system and constant exposure to Earth’s magnetic fields and other sources, there has been scant knowledge regarding the role of electromagnetic stimuli in neurogenesis. Moreover, the emerging application of electrical and magnetic stimulation to treat neurological disorders emphasizes the relevance of understanding the impact and mechanisms behind these stimuli. Here, the effects of magnetic nanoparticles (MNPs) contained in polymeric coatings and the static external magnetic field (EMF, 0.4 Tesla) were investigated on neural induction of murine embryonic stem cells (mESCs) and human induced pluripotent stem cells (hiPSCs) into induced dopaminergic neurons (iDA).

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Magnetic-field-driven targeting of exosomes modulates immune and metabolic changes in dystrophic muscle.

Project description:Exosomes are promising therapeutics for tissue repair and regeneration to induce and guide appropriate immune responses in dystrophic pathologies. However, manipulating exosomes to control their biodistribution and targeting them in vivo to achieve adequate therapeutic benefits still poses a major challenge. Here we overcome this limitation by developing an externally controlled delivery system for primed annexin A1 myo-exosomes (Exomyo). Effective nanocarriers are realized by immobilizing the Exomyo onto ferromagnetic nanotubes to achieve controlled delivery and localization of Exomyo to skeletal muscles by systemic injection using an external magnetic field. Quantitative muscle-level analyses revealed that macrophages dominate the uptake of Exomyo from these ferromagnetic nanotubes in vivo to synergistically promote beneficial muscle responses in a murine animal model of Duchenne muscular dystrophy. Our findings provide insights into the development of exosome-based therapies for muscle diseases and, in general, highlight the formulation of effective functional nanocarriers aimed at optimizing exosome biodistribution.

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Project description:Implantable devices for localized and controlled drug release are important, e.g., for therapies of cancer and chronic pain. However, most of the existing active implants are limited by the usage of nonbiodegradable materials; thus, surgery is needed to extract them after the treatment, which leads to secondary damage. Here, we show a fully biodegradable composite membrane made from silk fibroin and magnetic nanoparticles (MNPs). The membrane porosity can be remotely modified by an alternating magnetic field, which opens nanopores by local heating of MNPs in the composite allowing a liquid to diffuse through them. The stability of the silk membrane in water can be prolonged up to several months by increasing its β-sheet content through ethanol annealing. We present the following original findings. (a) Nanopores can be generated inside the silk/MNP composite membrane by exposing it to an external alternating magnetic field. (b) A longer exposure time results in more nanopore sites. (c) The controllable release of rhodamine B dye is achieved by tuning the period of exposure to the magnetic field. The obtained results demonstrate the suitability of the investigated silk/MNP composite membrane as a potential functional material for implantable drug delivery.

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