Project description:Effects of oil pollution and persistent organic pollutants (POPs) on the glycerophospholipids in the liver of male Atlantic cod (Gadus morhua)
Project description:Accumulating evidence suggests that poly- and perfluoroalkyl substances (PFAS), a class of persistent organic pollutants, cause changes in hepatic lipid, amino acid, and glucose metabolism. Our study explores the molecular mechanisms whereby PFHpA disrupts liver metabolism and facilitate NAFLD development.
Project description:Accumulating evidence suggests that poly- and perfluoroalkyl substances (PFAS), a class of persistent organic pollutants, cause changes in hepatic lipid, amino acid, and glucose metabolism. Our study explores the molecular mechanisms whereby PFHxS, PFOA, PFOS, and PFNA disrupt liver metabolism.
Project description:Transcriptional Regulation in Testis Associated with Developmental and Reproductive Effects in Male Zebrafish Exposed to Natural Mixtures of Persistent Organic Pollutants from Mjosa Lake
Project description:Transcriptional Regulation in liver and ovary associated with developmental and reproductive effects in female Zebrafish exposed to natural mixtures of persistent organic pollutants from Lake Mjosa or Lake Losna
Project description:A microarray analysis (transcriptome analysis) was conducted to examine estrogen-mediated gene expression in the arcuate nucleus (ARC) and paraventricular nucleus (PVN) of the hypothalamus, as well as the nucleus of the solitary tract (NTS) in female rats (Rattus norvegicus). All procedures were approved by the Oklahoma State University - Center for Health Sciences IACUC (protocol #2021-1278). Rats underwent ovariectomy, recovered, and were then treated with either 17β-estradiol (EB) or an oil vehicle (Oil). Following euthanasia, mRNA was extracted and submitted to Thermo Fisher Scientific for microarray analysis using the Clariom S Rat Pico Assay.
Project description:Exposure to Persistant Organic Pollutants (POPs) is known to cause serious health effects in human but the gene expression profiles leading to development of differnet diseases and disorders are not fully understood. The knowledge of global gene expression will help us to devlop early disease or disorder biomarkers for POP induced health effects. We used microarrays to detail the global gene expression profile underlying the effects of high POP exposure to Slovak 45 month children leading to identification of distinct classes of up-regulated and down-regulated genes and cellular processes.
