Project description:Petroselinum crispum var. neapolitanum Danert (Apiaceae) (PC), popularly known as parsley, is an herb native to the Mediterranean region widely cultivated around the world for culinary and ethnomedicinal purposes. The herb is traditionally used in various parts of the world to treat arterial hypertension, hemorrhoid, nose bleeding, hyperlipidemia, and pain, among other indications. The aim of this study was to evaluate the antithrombotic activity of an aqueous extract PC in rats. Aerial parts of a flat-leaf variety of parsley were extracted by decoction. In vivo thrombosis in rat models as well as ex vivo assays were used in the evaluation of PC antithrombotic effects. Intravenous administration of PC (25 mg/kg.b.w), 5 min before thrombosis induction, reduced the venous thrombus formation by 98.2%, while oral administration (125 mg/kg.b.w) impaired it by 76.2%. In the arterial thrombosis model, the oral administration of PC at 15 or 25 mg/kg.b.w, 60 min before thrombosis induction, increased the carotid artery occlusion time by 150% (37.0 ± 6.44 min) and 240% (more than 60 min), respectively. A HPLC-DAD-MS/MS profile of PC extract used in this study was provided. Apiin showed to be the most abundant phenolic compound in the extract. It also revealed the presence of many coumaric acid derivatives. Our results indicate that PC is a potential candidate for the development of a phytotherapeutic drug in the treatment of thromboembolic diseases and provide a detailed chemical profile useful for controlling PC extract production in view of phytotherapy.

| S-EPMC8116669 | biostudies-literature

Effects of Foliar Application of Copper and Gold Nanoparticles on Petroselinum crispum (Mill.).

Project description:The unintentional release of nanoparticles in the atmosphere and their targeted application to improve plant productivity requires detailed study. The translocation features of copper and gold nanoparticles applied by spraying in the concentration range of 1-100 mg/L in Petroselinum crispum (Mill.) tissues during a 10-day experiment were investigated. Atomic absorption spectrometry and inductively coupled plasma atomic emission spectroscopy showed that copper and gold nanoparticles applied to the leaves' surface could accumulate in plant organs. A dose-dependent increase in the content of copper and gold in the aerial parts of parsley was revealed. The content of copper in leaves treated with nanoparticles was 1-2.3 times higher than the control, while the content of gold exceeded control values 2-116 times. The effect of nanoparticles on plants' biochemical composition was assessed. The antioxidant tests showed an ambiguous response at exposure to metal nanoparticles. Copper nanoparticles at the applied concentration consistently reduced both chlorophyll and carotenoid content. Gold nanoparticles enhanced the chlorophyll and carotenoid level at low concentrations (1 mg/L) and significantly inhibited it at higher concentrations. The parsley exposed to nano-copper remained safe for human consumption, but parsley containing more than 14.9 mg/kg of gold may adversely affect human health.

| S-EPMC11858691 | biostudies-literature

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