Project description:Using whole genome bisulfite sequencing to provide single-base resulution of DNA methylation status in apple fruits ( Malus x domestica Borkh. ) in four different stages.
Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Project description:In order to compare sexual and asexual multiplication in Malus domestica we performed bisulfite sequencing to study change in differentially methylated region
Project description:Illumina Infinium apple 20K SNP array data from various studies used for building a Malus species specific allele library in the study "Identifying the contributions of progenitor Malus species to cultivated apple (M. domestica) using 20K SNP array data\