Project description:To gain a comprehensive understanding of the alterations in the tumor microenvironment following FOXM1 depletion in breast cancer cells, we employed single-cell RNA sequencing (scRNA-seq) on tumor samples from control and FOXM1 knockout groups.
Project description:Gene expression from epidydimal fat pad of wild type C57BL6/J and Apoliprotein E (EKO) mice on C57BL6/J mice Whole tissue of wild type and EKO mice fed with normal and high fat diet (3 and 4 biological replicates)
Project description:E0771 tumors were implanted either subcutaneously on the left flank or orthotopically in the mammary fat pad and treated with either PBS or FEC + oHSV-1 Mice were sacrificed 5 days after the start of treatment and whole tumour digests were used for RNA extraction
Project description:To invesitigate the additional paracaspase-independent tumor-promoting effect exist for Malt1. We thus collected E0771-Vector control tumor tissue, E0771 wildtype Malt1 (Malt1-WT) overexpression tumor tissue and E0771 paracaspase-deficient Malt1 (Malt1-PD) overexpression tumor tissue, and sorted out immune cells for 10× Genomics single cell RNA-sequencing (scRNA-seq).