Project description:Adeno-associated virus serotype 9 (AAV9) is currently considered the benchmark vector for clinical cardiac gene transfer applications but can entail severe hepatotoxicity due to its strong hepatotropism. Against this background, we report the discovery of a novel AAV capsid (cap) isolated from human myocardium that uniquely combines cardiospecificity with cardiotropism in vivo and bears potential to impact future cardiac gene therapy developments.

2025-05-07 | GSE290777 | GEO

adeno-associated virus 2

Project description:Adeno-associated virus (AAV) serotype 2 capsid (cap) gene directed evolution

| PRJNA196212 | ENA

adeno-associated virus 2

Project description:Adeno-associated virus (AAV) serotype 2 assembly activating protein (AAP) gene directed evolution

| PRJNA196213 | ENA

Adeno-associated virus-mediated delivery of anti-miR-199a tough decoys attenuates cardiac hypertrophy

Project description:MicroRNAs (miRNAs) are important regulators in the process of cardiac hypertrophy and heart failure. Previous studies showed that miR-199a is upregulated in pressure-overload cardiac hypertrophy and overexpression of miR-199a induces cardiac hypertrophy in vivo. However, the therapeutic role of anti-miR-199a treatment in cardiac hypertrophy is of little known. Here, we showed a novel and effective way to treat mice cardiac hypertrophy and restored cardiac function through injection of adeno-associated virus (AAV) which expressed anti-miR-199a tough decoys (TuDs). We performed the RNA-seq profiling in both AAV9-EGFP control and AAV9-anti-miR-199a TuDs injected cardiac hypertrophic mice. The transcriptome analysis indicates that genes related to cytoplasmic translation, mitochondrial respiratory chain complex assembly were upregulated by anti-miR-199a treated recovered hearts.

2020-12-31 | GSE155545 | GEO

adeno-associated virus 2

Project description:Adeno-associated virus type 2 transcriptome analysis by Illumina-based RNA sequencing (RNA-Seq)

| PRJNA322856 | ENA