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Transcriptomic changes in lens epithelial cells at 72 hours post cataract surgery

ABSTRACT: Transcriptomic changes in lens epithelial cells at 72 hours post cataract surgery

PROVIDER: PRJNA1109422 | ENA |

REPOSITORIES: ENA

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Transcriptomic changes in lens epithelial cells at 72 hours post cataract surgery

Project description:This trancriptomic analysis describes the gene expression changes observed in wildtype lens epithelial cells (LECs) by 72 hours compared to zero hours post cataract surgery

2025-08-05 | GSE267060 | GEO

Lens epithelial cell transcriptome reprogramming at 24 hours post cataract surgery

Project description:This trancriptome analysis reveals the first detailed analysis on how the remnant lens epithelial cells (LECs) greatly reprogram their transcriptome towards inflammation/fibrosis by 24 hours post cataract surgery (PCS).

2018-10-18 | GSE111430 | GEO

Transcriptomic changes in lens epithelial cells at 5 days post cataract surgery

Project description:This trancriptomic analysis describes the gene expression changes observed in wildtype lens epithelial cells (LECs) by 5 days compared to zero hours post cataract surgery

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Lens epithelial cell transcriptome reprogramming at 24 hours post cataract surgery

Project description:Lens epithelial cell transcriptome reprogramming at 24 hours post cataract surgery

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Lens epithelial cell transcriptome reprogramming at 48 hours post cataract surgery (PCS) in wild type (WT) and Fibronectin Conditional Knockout (FNcKO) mice

Project description:This trancriptome analysis reveals the first detailed analysis on how the remnant lens epithelial cells (LECs) greatly reprogram their transcriptome by 48 hours post cataract surgery (PCS) and the dependence of this phenomenom on endogenous fibronectin gene expression.

2020-07-08 | GSE119879 | GEO

Lens epithelial cell transcriptome reprogramming at 24 hours post cataract surgery (PCS) in wild type (WT) and β8 integrin Conditional Knockout (β8ITGcKO) mice.

Project description:This trancriptome analysis reveals the first detailed analysis on how the remnant lens epithelial cells (LECs) greatly reprogram their transcriptome by 24 hours post cataract surgery (PCS) and the dependence of this phenomenom on endogenous β8 integrin gene expression.

2021-12-15 | GSE145492 | GEO

RNA-seq Analysis of Human Lens Capsules from Donors with and without Cataract Surgery History

Project description:Cataract surgery is the most commonly performed ophthalmic procedure worldwide, yet the long-term molecular adaptations of lens epithelial cells (LECs) following surgery remain poorly understood. In this study, we conducted bulk RNA sequencing on lens capsules from 34 human donors, including 17 with an average of 7 years post-cataract surgery and 17 non-cataract controls. Differential expression analysis revealed substantial transcriptional changes in post-surgical LECs, including 1,690 upregulated and 579 downregulated genes. Gene Set Enrichment Analysis (GSEA) and Gene Ontology (GO) analyses identified activation of oxidative stress response, cell survival pathways, and immune response signatures. Collectively, our findings reveal that LECs undergo profound and sustained molecular reprogramming following cataract surgery, including inflammatory, fibrotic, migratory, and senescent changes. These adaptations may contribute to posterior capsule opacification (PCO) and highlight potential therapeutic targets for its prevention.

2025-07-23 | GSE295383 | GEO

Changes in gene expression time 0 vs. 1hr post-cataract sugery wounding in the lens

Project description:Early changes in the transcriptome associated with lens wounding in an ex vivo post-cataract surgery chicken model. Here we report the changes in the transcriptome that occur 1hr vs. time 0 post-cataract surgery wounding. Our data provide a molecular framework for understanding the early gene changes associated with the injury response of the lens.

2023-11-04 | GSE239368 | GEO

Transcriptomic signatures associated with regenerative wound vs. fibrotic repair outcomes to lens post-cataract surgery wounding

Project description:RNAseq analysis was used to determine the transcriptomic changes associated with regenerative vs. fibrotic repair to lens injury. Using an ex vivo post-cataract surgery model, we can follow two distinct outcomes to lens injury: 1) A regenerative wound healing response that ensues across the cell-denuded lens capsule basement membrane (BM), culminating in wound closure on Day 3 (D3) post-injury. 2) Induction of fibrosis, which occurs when a wound healing response occurs off the lens capsule, termed the extracapsular zone (ECZ), where transition to a fibrotic phenotype occurs on day 3 post-injury. Here, we report the changes in the transcriptome that occur on D1, D2, and D3 post-injury, a period that covers wound healing across the BM and time points prior to (D1, D2) and after induction of the fibrotic phenotype (D3). Our data provides a molecular map for understanding the gene changes associated with navigating normal and pathological outcomes to lens injury.

2025-06-02 | GSE298481 | GEO

The influence of sex and age on the lens injury response

Project description:The purpose of this study was to investigate/characterize age- and sex-dependent changes in transcriptomic profile in a mouse model of cataract surgery that mimics human cataract surgery. This surgery involves the removal of lens fiber cells (LFC) leaving behind the lens capsule and associated lens epithelial cells (LEC). The lens capsule and associated remnant LECs were harvested either following cataract surgery (0 hour) or 24 hours later. Fiber cells were collected at the time of surgery, equivalent to 0 hour, and analyzed separately from epithelial cells. For samples from LEC, each biological replicate is a pool of 5 lens capsules from 5 independent mice. For samples from LFC, each biological replicate is a pool of 2 fiber cell masses from two independent mice. Mice were either 24 months old (Aged), or 3 months old (Young).

2021-07-10 | GSE166619 | GEO

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