Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-nuclei multiome (ATAC + Gene Expression) sequencing of CD40L-activated human plasmacytoid dendritic cells

ABSTRACT: Single-nuclei multiome (ATAC + Gene Expression) sequencing of CD40L-activated human plasmacytoid dendritic cells

PROVIDER: PRJNA1109766 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28980802_1.fastq.gz	Fastqsanger.gz
	SRR28980802_2.fastq.gz	Fastqsanger.gz
	SRR28980803_1.fastq.gz	Fastqsanger.gz
	SRR28980803_2.fastq.gz	Fastqsanger.gz
	SRR28980804.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Single-nuclei multiome (ATAC + Gene Expression) sequencing of human plasmacytoid dendritic cells

Project description:Single-nuclei multiome (ATAC + Gene Expression) sequencing of human plasmacytoid dendritic cells

| PRJNA1110164 | ENA

Single-nuclei multiome (ATAC + Gene Expression) sequencing of CD40L-activated human plasmacytoid dendritic cells

Project description:Plasmacytoid and conventional dendritic cells (pDCs and cDCs, respectively) are closely related immune lineages with distinct functions. Whether pDCs can switch fate into the cDC lineage has remained controversial. Here, we sequenced purified pDCs and DCs to create a reference map of the transcriptome and chromatin landscape of all major human blood DC populations (GSE267174 and GSE267100). We compared this reference map to the transcriptomic and epigenetic profile of activated pDCs (GSE267099 and GSE266889). We show that activation of purified, bona fide human pDCs induces transcriptional and epigenetic heterogeneity at the single-cell level. A fraction of activated pDCs retains classical pDC features, while others acquire a cDC2-like identity through an intermediate state resembling transitional dendritic cells (tDCs). These datasets—generated using single-cell multiomic profiling (scRNA-seq and scATAC-seq) and SMART-seq—provide a resource to investigate the molecular basis of pDC-to-cDC2 fate transition.

2025-06-13 | GSE267099 | GEO

Single-nuclei multiome (ATAC + Gene Expression) sequencing of human plasmacytoid dendritic cells

2025-06-13 | GSE267174 | GEO

Single-nuclei multiome (ATAC + Gene Expression) sequencing of purified human dendritic cells

Project description:Single-nuclei multiome (ATAC + Gene Expression) sequencing of purified human dendritic cells

| PRJNA1109770 | ENA

Methylation data profiling for blastic plasmacytoid dendritic cell neoplasm

Project description:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive malignancy assumed to originate from plasmacytoid dendritic cells (pDCs), which affects the skin and bone marrow and sequentially other organ systems. Here, we used EPIC arrays to characterize methylation profiles in 51 BPDCN cases.

2024-02-11 | GSE230487 | GEO

Transcription profiling of human plasmacytoid dendritic cells treated with p17 or CpG

Project description:We used microarrays to detail the global program of gene expression underlying the effect of p17 on human plasmacytoid dendritic cells and was compared to CpG profile. Experiment Overall Design: Human plasmacytoid dendritic cells were purified from two donors and cultured in the presence of p17 or CpG for 18 h.

2008-04-07 | E-GEOD-10147 | biostudies-arrayexpress

Blastic plasmacytoid dendritic cell neoplasm (BPDCN)_cases

Project description:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that is most similar in expression profiles to plasmacytoid dendritic cells. However, patients often exhibit features of AML and can progress to AML. In this project, we will determine the differentially and commonly expressed genes between BPDCN and AML specimens. Available BPDCN and TET2-mutated AML specimens were taken for transcriptome microarray analysis.

| EGAD00010001727 | EGA

Molecular landscape of blastic plasmacytoid dendritic cell neoplasm

Project description:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive malignancy assumed to originate from plasmacytoid dendritic cells (pDCs), which mostly affects the skin, bone marrow and lymph nodes and sequentially other organ systems. We applied paired WES/RNA-seq combined with genome-wide copy-number analysis to characterize 47 BPDCN patients regarding mutational drivers, cytogenetic aberrations and gene-expression profiles.

| EGAS00001006166 | EGA

Continuous expression of the transcription factor E2-2 maintains the cell fate of mature plasmacytoid dendritic cells

Project description:This SuperSeries is composed of the following subset Series: GSE24726: Gene expression profile of mature plasmacytoid dendritic cells (PDC) after the deletion of transcription factor E2-2 GSE24740: Binding targets of transcription factor E2-2 in human plasmacytoid dendritic cells Refer to individual Series

2010-12-21 | E-GEOD-24785 | biostudies-arrayexpress

Single-nuclei multiome (ATAC + Gene Expression) sequencing of purified human dendritic cells

2025-06-13 | GSE267100 | GEO