Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-nuclei multiome (ATAC + Gene Expression) sequencing of purified human dendritic cells

ABSTRACT: Single-nuclei multiome (ATAC + Gene Expression) sequencing of purified human dendritic cells

PROVIDER: PRJNA1109770 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR28982255_1.fastq.gz	Fastqsanger.gz
	SRR28982255_2.fastq.gz	Fastqsanger.gz
	SRR28982256.fastq.gz	Fastqsanger.gz
	SRR28982257.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Single-nuclei multiome (ATAC + Gene Expression) sequencing of human plasmacytoid dendritic cells

Project description:Single-nuclei multiome (ATAC + Gene Expression) sequencing of human plasmacytoid dendritic cells

| PRJNA1110164 | ENA

Single-nuclei multiome (ATAC + Gene Expression) sequencing of purified human dendritic cells

Project description:Plasmacytoid and conventional dendritic cells (pDCs and cDCs, respectively) are closely related immune lineages with distinct functions. Whether pDCs can switch fate into the cDC lineage has remained controversial. Here, we sequenced purified pDCs and DCs to create a reference map of the transcriptome and chromatin landscape of all major human blood DC populations (GSE267174 and GSE267100). We compared this reference map to the transcriptomic and epigenetic profile of activated pDCs (GSE267099 and GSE266889). We show that activation of purified, bona fide human pDCs induces transcriptional and epigenetic heterogeneity at the single-cell level. A fraction of activated pDCs retains classical pDC features, while others acquire a cDC2-like identity through an intermediate state resembling transitional dendritic cells (tDCs). These datasets—generated using single-cell multiomic profiling (scRNA-seq and scATAC-seq) and SMART-seq—provide a resource to investigate the molecular basis of pDC-to-cDC2 fate transition.

2025-06-13 | GSE267100 | GEO

Single-nuclei multiome (ATAC + Gene Expression) sequencing of CD40L-activated human plasmacytoid dendritic cells

Project description:Single-nuclei multiome (ATAC + Gene Expression) sequencing of CD40L-activated human plasmacytoid dendritic cells

| PRJNA1109766 | ENA

Multiome RNA+ATAC on human PBMCs (snRNA-seq data)

Project description:We generated Multiome RNA+ATAC data from the same cell from human PBMC. This served as a gold benchmark for a novel integration method for multi-omics data that we developed.

2021-12-02 | E-MTAB-11225 | biostudies-arrayexpress

Multiome RNA+ATAC on human PBMCs (snATAC-seq data)

Project description:We generated Multiome RNA+ATAC data from the same cell from human PBMC. This served as a gold benchmark for a novel integration method for multi-omics data that we developed.

2021-12-02 | E-MTAB-11226 | biostudies-arrayexpress

Single-nuclei multiome (ATAC + Gene Expression) sequencing of human plasmacytoid dendritic cells

2025-06-13 | GSE267174 | GEO

Single-nuclei multiome (ATAC + Gene Expression) sequencing of CD40L-activated human plasmacytoid dendritic cells

2025-06-13 | GSE267099 | GEO

Transcriptional Activation of Regenerative Haematopoiesis via Niche Sensing [snRNA/ATACseq HSPC Multiome]

Project description:Multiome single nuclei RNA/ATAC-seq analysis was performed on sorted population of SLAM LSK HSPCs to uncover transcriptional determinants regulating HSPCs in distinct transitional states.

2024-04-01 | GSE208039 | GEO

Multiome single-cell RNA and ATAC sequencing from Young and Old Hematopoietic Stem Cells (HSCs)

Project description:We used multiome single cell RNA and ATAC (scRNA+scATAC) sequencing to analyze the heterogeneity in young and old HSCs

2025-06-02 | GSE246464 | GEO

Single-cell RNA+ATAC sequencing of human CRL-1459 colonic fibroblasts

Project description:The 10x multiome (RNA+ATAC) kit was applied to CRL-1459 cells in culture at passage 10 and 15

2024-07-13 | E-MTAB-14220 | biostudies-arrayexpress