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ABSTRACT: N6-induced-Staphylococcus aureus-SA113, YUSA145, CHS101

PROVIDER: PRJNA1110295 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28996353_1.fastq.gz	Fastqsanger.gz
	SRR28996353_2.fastq.gz	Fastqsanger.gz
	SRR28996354_1.fastq.gz	Fastqsanger.gz
	SRR28996354_2.fastq.gz	Fastqsanger.gz

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Project description:IOWH-032- SA113, YUSA145

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Project description:Staphylococcus aureus strain:SA113 | isolate:Standard strain SA113 Transcriptome or Gene expression

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Human whole blood stimulated with Pam2Cys and lipoteichoic acid from Staphylococcus aureus wt and delta-lgt mutant

Project description:Comparison of the immune response of human whole blood to lipoteichoic acid (LTA) derived from the Staphylococcus aureus SA113 delta-lgt mutant (lacks lipoproteins), LTA from S. aureus SA113 wt. and PAM2Cys, a lipoprotein analogue. Background: Our goal was to expand our report that LTA from SA 113 wildtype (wt LTA) and delta-lgt (lgt LTA) induce equal amounts of TNF release by human whole blood (von Aulock et al., J Immunol, 2007). Therefore we traced the translational activation by both LTA in comparison to the synthetic diacylated lipoprotein Pam2Cys-SK4 in human whole blood on an immunology microarray comprising 1076 genes related to apoptosis and signal transduction, cell cycle, chemokines, cytokines and their receptors, extracellular matrix proteins, inflammation and complement system. Results and Discussion: The results show extensive overlaps of the clustered heat-maps of SA113 wt and lgt LTA, which are clearly different from those of Pam2Cys-SK4 stimulation. Only four of the 1076 genes were significantly differently regulated after stimulation with the LTAs, whereas stimulation with Pam2Cys-SK4 led to a significantly different regulation of 43 genes compared to SA 113 wt LTA and 39 compared to SA 113 lgt LTA. Mainly chemokines were upregulated by both LTA, which is consistent with our previous findings (von Aulock et al., Immunobiol, 2003) and different from stimulations with Pam2Cys-SK4. The gene array results support our protein data obtained from LTA-stimulated human whole blood and point to a significant concordance between the immunostimulatory activity of lgt and wt LTA preparations. In contrast, a distinct difference is observed between both LTA and the synthetic lipoprotein Pam2Cys-SK4. This supports the conclusion that the immunostimulatory activity of wt LTA in human whole blood is not determined by possible lipoprotein contaminations.

2015-04-05 | GSE21188 | GEO

Genomic comparison of vancomycin susceptible and vancomycin intermediate Staphylococcus aureus pairs

Project description:To determine if significant genomic changes are associated with the development of vancomycin intermediate Staphylococcus aureus, genomic DNA microarrays were performed to compare the initial vancomycin susceptible Staphylococcus aureus (VSSA) and a related vancomycin intermediate Staphylococcus aureus (VISA) isolate from five unique patients (five isolate pairs). Keywords: comparative genomic hybridization

2006-11-03 | GSE5047 | GEO

Global transcriptional profiling of Staphylococcus aureus treated with rhein

Project description:Staphylococcus aureus is one of the most important pathogens in humans and animals, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. Rhein, a natural plant product, has potential antimicrobial activity against Staphylococcus aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with rhein. Results provided insight into mechanisms involved in rhein - Staphylococcus aureus interactions. Keywords: rhein response

2007-06-15 | GSE8135 | GEO

Metabolic and transcriptional activities of Staphylococcus aureus challenged with high-doses of daptomycin

Project description:Treatment of stationary growth phase Staphylococcus aureus SA113 with 100-fold of the MIC of the lipopeptide antibiotic daptomycin leaves alive a small fraction of drug tolerant albeit genetically susceptible bacteria. This study shows that cells of this subpopulation exhibit active metabolism even hours after the onset of the drug challenge. Isotopologue profiling using fully 13C-labeled glucose revealed de novo biosynthesis of the amino acids Ala, Asp, Glu, Ser, Gly and His. The isotopologue composition in Asp and Glu suggested an increased activity of the TCA cycle under daptomycin treatment compared to unaffected stationary growth phase cells. Microarray analysis showed differential expression of specific genes 10 minutes and 3 hours after addition of the drug. Besides factors involved in drug response, a number of metabolic genes appear to shape the signature of daptomycin-tolerant S. aureus cells. These observations will be useful towards the development of new strategies against persisters and related forms of bacterial cells with downshifted physiology.

2014-06-06 | GSE57908 | GEO

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Project description:In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to hydrogen peroxide-induced oxidative stress, which involved initial growth inhibition and subsequent recovery. Keywords: Time course

2005-12-31 | GSE3415 | GEO

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