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ATAC-Seq experiment of major tissues from wild-type mice under fasting and fed treatments

ABSTRACT: ATAC-Seq experiment of major tissues from wild-type mice under fasting and fed treatments

PROVIDER: PRJNA1110967 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29006143_1.fastq.gz	Fastqsanger.gz
	SRR29006143_2.fastq.gz	Fastqsanger.gz
	SRR29006144_1.fastq.gz	Fastqsanger.gz
	SRR29006144_2.fastq.gz	Fastqsanger.gz
	SRR29006145_1.fastq.gz	Fastqsanger.gz

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ATAC-Seq experiment of major tissues from wild-type mice under fasting and fed treatments

Project description:Male C57BL/6 mice, sourced from the Jackson Laboratory, were acquired at 12 weeks of age. The mice were housed in groups of three per cage, with unrestricted access to water and a standard chow diet. For the experimental treatments involving fasting and fed states (n = 3 per group), the mice were either provided continuous access to food or subjected to a 24-hour fasting period before euthanasia at 10 am for tissue collection. The tissues harvested included muscle, liver, heart, lungs, both white and brown adipose tissues, spleen, and kidney. These tissues were immediately preserved in liquid nitrogen post-sacrifice to maintain their integrity for subsequent analyses.

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Genes regulated by nuclear Lipin in the fed and fasting state

Project description:Lipins are eukaryotic proteins with functions in lipid synthesis and the homeostatic control of energy balance. They execute these functions by acting as phosphatidate phosphatase enzymes in the cytoplasm and by changing gene expression after translocation into the cell nucleus, in particular under fasting conditions. Here, we asked how gene expression changes, under both fed and fasting conditions, when nuclear translocation of Lipin is impaired. To address this question, we created a Drosophila mutant expressing Lipin lacking a nuclear localization signal (LipinDNLS). Notably, adult LipinDNLS flies were not only viable but also exhibited improved life expectancy. In contrast, they were highly susceptible to starvation. To examine how these phenotypes correlate with changes in gene expression, we carried out an RNA-seq analysis with mRNA from female and male LipinDNLS and control flies that had been kept under fed or fasting conditions. We found that genes involved in metabolism, feeding behavior, and the immune response were mis-regulated in LipinDNLS flies. The changed expression of these genes supports hypotheses explaining improved life expectancy under fed and decreased life expectancy under fasting conditions. For instance, metabolic rate measurements confirmed the prediction based on the RNA-seq data that energy production by oxidative phosphorylation is reduced in fed LipinDNLS flies.

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