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Impact of parental obesity on adipose progenitor programming

ABSTRACT: Impact of parental obesity on adipose progenitor programming

PROVIDER: PRJNA1110991 | ENA |

REPOSITORIES: ENA

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Impact of parental obesity on adipose progenitor programming

Project description:Parental obesity (PO) increases the risk of obesity and metabolic syndromes in offspring. To investigate how PO influences adipose progenitors, we generated offspring from lean (Ln-F1) or obese (Ob-F1) parents and isolated the stromal vascular fraction (SVF) from inguinal white adipose tissue (iWAT) depots at postnatal day 21 (P21). Bulk RNA sequencing of the SVF was performed to uncover the molecular mechanisms by which PO programs adipose progenitors.

2025-07-22 | GSE267285 | GEO

Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

Project description:Obesity is a global rising problem with epidemiological dimension. Obese parents can have programming effects on their offspring leading to obesity and associated diseases in later life. This constitutes a vicious circle. Epidemiological data and studies in rodents demonstrated differential programming effects in male and female offspring, but the timing of their developmental origin is not known. This study investigated if sex-specific programming effects of parental obesity can already be detected in the pre-implantation period. Diet induced obese male or female mice were mated with normal-weight partners and blastocysts were recovered. Gene expression profiling revealed sex-specific responses of the blastocyst transcriptome to maternal and paternal obesity. The changes in the transcriptome of male blastocysts were more pronounced than those of female blastocysts, with a stronger impact of paternal than of maternal obesity. The sperm of obese mice revealed an increased abundance of several miRNAs compared to lean mice. Our study indicates that sex-specific programming effects of parental obesity already start in the pre‑implantation period and reveals specific alterations of the sperm miRNA profile as mechanistic link to programming effects of paternal obesity.

2019-07-07 | GSE133915 | GEO

Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development

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small RNA reads sperm parental obesity

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development_small RNASeq Data of Sperm

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

| PRJNA553001 | ENA

Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

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Adipose Tissue Omics In Obesity

Project description:Adipose Tissue Omics In Obesity

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