Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Xap5 protects against necrotic apoptosis induced by overdevelopment in adipocytes.

ABSTRACT: Xap5 protects against necrotic apoptosis induced by overdevelopment in adipocytes.

PROVIDER: PRJNA1113175 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR29077454_1.fastq.gz	Fastqsanger.gz
	SRR29077454_2.fastq.gz	Fastqsanger.gz
	SRR29077455_1.fastq.gz	Fastqsanger.gz
	SRR29077455_2.fastq.gz	Fastqsanger.gz
	SRR29077456_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Xap5 protects against necrotic apoptosis induced by overdevelopment in adipocytes.

Project description:The development and death of adipocytes play a crucial role in the metabolic stability of the body. We report that Xap5 plays a significant role in the development and death of adipocytes. The specific knockout of Xap5 in mature adipocytes leads to severe lipodystrophy in mice, subsequently causing metabolic disorders. By analyzing the development process of wild-type and Xap5 knockout adipocytes in vivo and in vitro, we found that the adipose deficiency caused by Xap5 knockout is mainly due to necroptosis caused by excessive development of adipocytes. Our results reveal a previously unrecognized role of Xap5 in adipocyte development and homeostasis.

2025-05-01 | GSE267815 | GEO

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

Project description:DAG-activated Pkd1 promotes triglyceride accumulation in adipocytes; Pkd1 promotes lipogenesis and suppresses mitochondrial function in adipocytes in an AMPK-dependent manner; Pkd1 suppresses expression of genes characteristic for beige adipocytes; Deletion of Pkd1 in adipocytes protects mice from diet-induced obesity, T2D and liver steatosis.

2018-09-20 | GSE104797 | GEO

A caspase-independent necrotic death is activated by isopeptidase inhibitor G5 in apoptosis-resistant glioblastoma cells

Project description:The regulation of necrotic death and its relevance in anti-cancer therapy are largely unknown. Here we have investigated the pro-apoptotic and pro-necrotic activities of two ubiquitin-proteasome system inhibitors (UPSIs): bortezomib and G5. The present study points out that the glioblastoma cell lines U87MG and T98G are useful models to study the susceptibility to apoptosis and necrosis in response to UPSIs. U87MG cells are resistant to apoptosis induced by bortezomib and G5 but susceptible to necrosis induced by G5. On the opposite T98G cells are susceptible to apoptosis induced by both inhibitors but show some resistance to G5-induced necrosis. By comparing the transcriptional profiles of the two cell lines, we have found that the resistance to G5-induced necrosis could arise from differences in glutathione synthesis/utilization and in the microenvironment. In particular collagen IV, which is highly expressed in T98G cells, and fibronectin, whose adhesive function is counteracted by tenascin-C in U87MG cells, can restrain the necrotic response to G5. Collectively, our results provide an initial characterization of the molecular signals governing cell death by necrosis in glioblastoma cell lines. Keywords: cell line comparison

2009-10-13 | GSE14889 | GEO

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

Project description:Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

| PRJNA413844 | ENA

Microarray transcription profiling of healthy and PVYNTN infected potato tuber tissues (necrotic and non-necrotic)

Project description:To extend our understanding of systemic necrosis in susceptible potato tubers infected with the necrotic strain of Potato virus Y (PVYNTN) gene expression was compared between healthy and infected non-necrotic and necrotic (both non-necrotic and necrotic tissue) potato tubers.

2018-05-16 | E-MTAB-5776 | biostudies-arrayexpress

Deletion of Bmal1 in Intestinal Epithelium Protects against Colonic Inflammation by Suppressing the Apoptosis Pathway

Project description:Deletion of Bmal1 in Intestinal Epithelium Protects against Colonic Inflammation by Suppressing the Apoptosis Pathway

| PRJNA1130917 | ENA

Deletion of Bmal1 in Intestinal Epithelium Protects against Colonic Inflammation by Suppressing the Apoptosis Pathway

Project description:Deletion of Bmal1 in Intestinal Epithelium Protects against Colonic Inflammation by Suppressing the Apoptosis Pathway

| PRJNA1130403 | ENA

Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis

Project description:Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis

| PRJNA851438 | ENA

tRF-Val-TAC-004 protects against renal ischemia-reperfusion injury via attenuating Apaf1-mediated apoptosis

Project description:tRF-Val-TAC-004 protects against renal ischemia-reperfusion injury via attenuating Apaf1-mediated apoptosis