Methylation Profiling for Pediatric Pineal Parenchymal Tumors
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1121213 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Pineal parenchymal body tumors are rare central nervous system tumors with a variety of presentations ranging from well-differentiated low-grade tumors to undifferentiated highly aggressive tumors. Recent molecular classification has described the heterogeneity among these tumors, particularly among pineoblastomas (PB) and papillary tumors of intermediate differentiation (PPTID). Herein, we describe the methylation profile for 20 pediatric pineal parenchymal tumors using Illumina Infinium Methylation EPIC BeadChip array and correlate it with the patients’ clinical data. Our findings support that these tumors are diverse, incorporating novel entities with distinct clinical features and the presence of medulloblastomas outside the posterior fossa.
2025-06-06 | GSE269319 | GEO
Project description:We identify and correlate chromosomal alterations, methylation patterns and gene expression in pediatric pineal germinomas. Due the low incidence of pineal germinoma, there is insufficient molecular data related to chromosomal alterations, methylation patterns and genetic expression that may help understand the changes that influence tumor development. In addition, at present, the diagnosis of this tumor in childhood is challenging because of its location and cellular origin, which is why our aim was to understand and to identify possible molecular biomarkers to provide information on the diagnosis and tumor development. Tumor biopsies were obtained from pediatric patients of 0 to 16 years of age, they were subsequently evaluated by histopathological analysis. Sample selection was based on the percentage of tumor cells present in the tumor samples, processing the samples containing the lowest 70% and 80% tumor cells, respectively.
2016-11-26 | E-MTAB-5107 | biostudies-arrayexpress
Project description:We identify and correlate chromosomal alterations, methylation patterns and gene expression in pediatric pineal germinomas. Due the low incidence of pineal germinoma, there is insufficient molecular data related to chromosomal alterations, methylation patterns and genetic expression that may help understand the changes that influence tumor development. In addition, at present, the diagnosis of this tumor in childhood is challenging because of its location and cellular origin, which is why our aim was to understand and to identify possible molecular biomarkers to provide information on the diagnosis and tumor development. Tumor biopsies were obtained from pediatric patients of 0 to 16 years of age, they were subsequently evaluated by histopathological analysis. Sample selection was based on the percentage of tumor cells present in the tumor samples, processing the samples containing the lowest 70% and 80% tumor cells, respectively.
2016-11-26 | E-MTAB-5108 | biostudies-arrayexpress
Project description:We identify and correlate chromosomal alterations, methylation patterns and gene expression in pediatric pineal germinomas. Due the low incidence of pineal germinoma, there is insufficient molecular data related to chromosomal alterations, methylation patterns and genetic expression that may help understand the changes that influence tumor development. In addition, at present, the diagnosis of this tumor in childhood is challenging because of its location and cellular origin, which is why our aim was to understand and to identify possible molecular biomarkers to provide information on the diagnosis and tumor development. Tumor biopsies were obtained from pediatric patients of 0 to 16 years of age, they were subsequently evaluated by histopathological analysis. Sample selection was based on the percentage of tumor cells present in the tumor samples, processing the samples containing the lowest 70% and 80% tumor cells, respectively.
2016-11-26 | E-MTAB-5106 | biostudies-arrayexpress
Project description:Methylation profiling of pediatric choroid plexus tumors
| PRJNA656763 | ENA
Project description:Tumor DNA methylation in pediatric germ cell tumors
| PRJNA762030 | ENA
Project description:Epigenomewide methylation profiling of tumor DNA from pediatric germ cell tumors by sex, tumor histology, tumor location and age at diagnosis. DNA methylation was measured using the Illumina Infinium HumanMethylation450 array
2021-09-11 | GSE183798 | GEO
Project description:Aggresome is a para nuclear inclusion body that functions as a storage compartment for misfolded proteins. Our previous work revealed the presence of aggresomes in pediatric choroid plexus tumors (CPT). CPTs are rare neoplasms comprised of three pathological subgroups; choroid plexus carcinoma (CPC), a grade III tumor, atypical choroid plexus papilloma (ACPP), a grade II tumor, and choroid plexus papilloma (CPP), a grade I tumor. In the current study, we aimed to investigate the prognostic value of aggresomes-positivity and its correlation to the pathological and molecular subtypes. The genome-wide methylation profile of 42 CPT pediatric samples was investigated using Illumina Infinium Methylation EPIC BeadChip array.
2021-01-21 | GSE156090 | GEO
Project description:Genomewide DNA methylation array profiling and analysis of 76 new and public published Papillary Tumor of the Pineal Region (PTPR). The methylation idat profiles of 39 newly profiled tumors were provided here.
2024-07-19 | GSE254031 | GEO
Project description:Abnormal DNA methylation contributes to tumor progression and is emerging as a prognostic marker in several types of cancers. To investigate whether DNA methylation is associated with Pediatric Adrenocortical Tumor (pACT) presentation and patient prognosis, we analyzed the methylation profile of 57 tumors (Illumina Infinium HumanMethylation850 BeadChip) and patients’ clinicopathological features and outcome.
2023-01-26 | GSE179175 | GEO