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Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons (scRNA-Seq)

ABSTRACT: Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons (scRNA-Seq)

PROVIDER: PRJNA1124995 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29445332_1.fastq.gz	Fastqsanger.gz
	SRR29445332_2.fastq.gz	Fastqsanger.gz
	SRR29445333_1.fastq.gz	Fastqsanger.gz
	SRR29445333_2.fastq.gz	Fastqsanger.gz

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Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons

Project description:Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons

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Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons

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Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons (CUT&Tag)

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Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons (CUT&Tag)

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Project description:Antigen encounter directs CD4+ T cells to differentiate into T-helper or -regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern -helper versus -regulatory fate remain poorly understood. Here, we show that the E3 ubiquitin ligase Cul5 determines fate selection in CD4+ T cells by regulating IL-4 receptor signaling. Mice lacking Cul5 in T cells developed enhanced Th2 and Th9 inflammation and pathophysiological features of atopic asthma upon allergen exposure. Following T cell activation, Cul5 formed a complex with CIS and pJak1. Loss of Cul5 function resulted in reduced ubiquitylation and increased stability of pJak1, elevated STAT6 activity, and a reduced threshold for IL-4 receptor signaling. In keeping with this, Cul5-deficient T cells deviated from Treg to Th9 differentiation in low IL-4 conditions. These data support that Cul5 promotes a tolerogenic T cell fate choice and reduces susceptibility to allergic asthma.

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Single cell analysis of the postnatal dorsal V-SVZ reveals a role for Bmpr1a-signaling in silencing pallial germinal activity

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