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Effect of depletion of IGF2BP3 on gene expression in LUAD

ABSTRACT: Effect of depletion of IGF2BP3 on gene expression in LUAD

PROVIDER: PRJNA1128042 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29542600_1.fastq.gz	Fastqsanger.gz
	SRR29542600_2.fastq.gz	Fastqsanger.gz
	SRR29542601_1.fastq.gz	Fastqsanger.gz
	SRR29542601_2.fastq.gz	Fastqsanger.gz
	SRR29542602_1.fastq.gz	Fastqsanger.gz

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Effect of depletion of IGF2BP3 on gene expression in LUAD

Project description:IGF2BP3, an oncofetal protein and an m6A reader, is a member of the IGF2BPs family playing an important role in cell migration in early embryogenesis, oncogenesis, metabolism and metastasis. To clarify the effect of depletion of IGF2BP3 on gene expression in LUAD, we conducted IGF2BP3 knocked out experiments in the NCI-H1299 LUAD cell lines. The knockout efficiency was validated by western blot analysis, demonstrating successful silencing of IGF2BP3 at the protein levels in NCI-H1299 cells. To explore the underlying mechanisms of IGF2BP3 in LUAD development, we conducted RNA-sequencing analysis using IGF2BP3 knockout and control NCI-H1299 cells, with each group consisting of three biological replicates. The analysis revealed that IGF2BP3 knockout resulted in differential expression of 1700 genes including 621 genes upregulated and 1079 downregulated.

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