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Effect of the expression of HP1 proteins from different species (mouse, fruit fly, fission yeast) in mouse 3T3 cells

ABSTRACT: Effect of the expression of HP1 proteins from different species (mouse, fruit fly, fission yeast) in mouse 3T3 cells

PROVIDER: PRJNA1131332 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR29692764_1.fastq.gz	Fastqsanger.gz
	SRR29692764_2.fastq.gz	Fastqsanger.gz
	SRR29692765_1.fastq.gz	Fastqsanger.gz
	SRR29692765_2.fastq.gz	Fastqsanger.gz

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Effect of the expression of HP1 proteins from different species (mouse, fruit fly, fission yeast) in mouse 3T3 cells

Project description:HP1 proteins play a role in heterochromatin regulation and higher-order chromatin organization. The domain structure of HP1 is conserved, but the properties and functions of HP1 homologs from different organisms might vary. To address this issue, we expressed HP1 from different species in mouse 3T3 cells and assessed the impact on gene expression by RNA-seq.

2025-06-12 | GSE271404 | GEO

The HP1 protein interactome of mouse embryonic stem cells

Project description:The family of Heterochromatin Protein 1 (HP1) consists of highly conserved proteins, which have important functions in the nucleus of eukaryotic cells. In mammals there are three HP1 paralogs: HP1(alpha), Hp1(beta), and Hp1(gamma)They are encoded by the Cbx5, Cbx1, and Cbx3 genes, respectively. Hp1 and Hp1 stably interact with Chd4 and Adnp to form the ChAHP complex. In this project, Chd4, Adnp, and the three Cbx genes were endogenously tagged with a FLAG-Avi tag in mouse embryonic stem cells. The tagged proteins were subjected to tandem-affinity purification and analysis by mass spectrometry.

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Multivalent H3K9me2 Reader ADCP1 Functions as a plant HP1 to Maintain Epigenetic Silencing

Project description:Heterochromatin formation is important for genome stability and transposon silencing. The evolutionally conserved Heterochromatin Protein 1 (HP1) recognizes H3K9me3 and maintains heterochromatin from fission yeast to mammalians. However, it is still questioned about the presence of HP1 protein in plants. Here, we discovered a multivalent H3K9me2 reader ADCP1 in Arabidopsis through biophysical and structural studies, and agenet domain in ADCP1 has the similar function of chromo domain in HP1. We further showed that ADCP1 was essential for heterochromatin maintenance through modulating H3K9me2 and DNA methylation levels. Similar to human HP1alpha and fly HP1a, ADCP1 was also able to mediate heterochromatin phase separation both in vitro and in vivo. Our results demonstrate the plant specific and evolution conserved ADCP1 functions as the HP1 equivalent protein in plant.

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3T3-L1: GDE5 Knockdown

Project description:Transcriptional profiling of mouse 3T3-L1 adipocytes. The objective of this study is to explore gene expression profiles of 3T3-L1 adipocytes in response to GDE5 siRNA transfection.

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Mouse NIH-3T3 cohesin TurboID LC-MSMS

Project description:The cohesin complex is a plieotropic regulator of genome structure and function. It is known to play a role in sister chromatin cohesin, DNA replication, DNA repair, and regulation of gene expression. Cohesin has several known interacting proteins that aid in the various roles within a nucleus, yet a comprehensive cohesin interactome has yet to be established. In this study, we utilized the biotin proximity ligation assay TurboID followed by LC-MS/MS in NIH-3T3 mouse fibroblast cells to identify novel proteins that interact with the cohesin complex.

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Expression data from cultured mouse BALB 3T3 cells containing bacterial plasmid gene mucAB

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2013-12-01 | GSE42927 | GEO

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