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Bcl11a is essential for B-1a cell maintenance during aging

ABSTRACT: Bcl11a is essential for B-1a cell maintenance during aging

PROVIDER: PRJNA1139750 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR29952023_1.fastq.gz	Fastqsanger.gz
	SRR29952023_2.fastq.gz	Fastqsanger.gz
	SRR29952024_1.fastq.gz	Fastqsanger.gz
	SRR29952024_2.fastq.gz	Fastqsanger.gz

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Bcl11a is essential for B-1a cell maintenance during aging (RNA-Seq)

Project description:B-1a cells are important immune cells, serving as the first line of defense against pathogens. B-1a cell undergo a series of alterations during aging and decrease the protection to our body. However, the characteristics of B-1a cells during the aging process are not fully understood. In this study, we discrible transcriptional and epigenetic profiles of B-1a from 3-month-old and 24-month-old mice across both genders. Interestingly，We found that the expression of the transcription factor Bcl11a was positively correlated with the number of B-1a cells in aged male and aged female mice.To further characterize senescent B-1a cells and the mechanisms of Bcl11a regulates B-1a. ATAC-seq and RNA-seq were performed on the B-1a isolated from young male mice (3-month-old),old male mice (24-month-old mice), young female mice (3-month-old),old female mice (24-month-old mice) of C57BL/6,and Bcl11a delated young male mice. CUT&tag was performed on the B-1a isolated from young male mice. Collectively, we provide a comprehensive resource to decode the aging process of B-1a, shedding light on how Bcl11a regulate B-1a cells maintenance.

2025-06-19 | GSE272987 | GEO

Bcl11a is essential for B-1a cell maintenance during aging (CUT&Tag)

2025-06-19 | GSE272986 | GEO

Bcl11a is essential for B-1a cell maintenance during aging (ATAC-Seq)

2025-06-19 | GSE272985 | GEO

Bcl11a is essential for B-1a cell maintenance during aging (RNA-Seq)

Project description:Bcl11a is essential for B-1a cell maintenance during aging (RNA-Seq)

| PRJNA1139754 | ENA

Bcl11a is essential for B-1a cell maintenance during aging (CUT&Tag)

Project description:Bcl11a is essential for B-1a cell maintenance during aging (CUT&Tag)

| PRJNA1139755 | ENA

Bcl11a is essential for B-1a cell maintenance during aging (scRNA-seq)

Project description:Bcl11a is essential for B-1a cell maintenance during aging (scRNA-seq)

| PRJNA1183301 | ENA

Bcl11a is essential for B-1a cell maintenance during aging (ATAC-Seq)

Project description:Bcl11a is essential for B-1a cell maintenance during aging (ATAC-Seq)

| PRJNA1139753 | ENA

Bcl11a is essential for B-1a cell maintenance during aging (scRNA-seq)

Project description:B-1a cells are important immune cells and are the first line of defence against pathogens. During aging, B-1a cells undergo a series of changes that reduce their protective effects on the body. However, the characteristics of B-1a cells during aging are not fully understood. In this study, we transcriptionally and epigenetically characterised B-1a cells from 3-month-old and 24-month-old mice. Interestingly, we found that the expression of the transcription factor Bcl11a was positively correlated with the number of B-1a cells in old male and old female mice. We performed single-cell sequencing from C57BL/6 young female mice (3 months of age), middle-aged female mice (15 months of age) old female mice (26 months of age) to characterise the senescence transition in female mice.

2025-06-19 | GSE281277 | GEO

Bcl11a is essential for B-1a cell maintenance during aging

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-06-19 | GSE272988 | GEO

Dendritic Cell Fate is Determined by BCL11A

Project description:Here we confirm an essential requirement for the BCL11A transcription factor in fetal pDC development, and for the first time demonstrate this lineage specific requirement in the adult organism. Genome-wide analyses of BCL11A DNA binding and expression revealed that BCL11A regulates transcription of E2-2 and other pDC differentiation modulators including ID2 and MTG16. Our results identify BCL11A as an essential, lineage-specific factor that regulates pDC development. ChIP sequenicng was performed for a transcription factor of BCL11A in Cal1 cell line. Input was sequenced and used as a control.

2014-02-15 | E-GEOD-55043 | biostudies-arrayexpress

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