Transcriptomics

Dataset Information

0

Bcl11a is essential for B-1a cell maintenance during aging (scRNA-seq)


ABSTRACT: B-1a cells are important immune cells and are the first line of defence against pathogens. During aging, B-1a cells undergo a series of changes that reduce their protective effects on the body. However, the characteristics of B-1a cells during aging are not fully understood. In this study, we transcriptionally and epigenetically characterised B-1a cells from 3-month-old and 24-month-old mice. Interestingly, we found that the expression of the transcription factor Bcl11a was positively correlated with the number of B-1a cells in old male and old female mice. We performed single-cell sequencing from C57BL/6 young female mice (3 months of age), middle-aged female mice (15 months of age) old female mice (26 months of age) to characterise the senescence transition in female mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE281277 | GEO | 2025/06/19

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2025-06-19 | GSE272986 | GEO
2025-06-19 | GSE272985 | GEO
2025-06-19 | GSE272987 | GEO
2010-05-26 | E-GEOD-7502 | biostudies-arrayexpress
2020-12-06 | GSE155005 | GEO
2021-03-10 | GSE168533 | GEO
2023-11-27 | GSE235942 | GEO
2024-09-10 | PXD026222 | Pride
2008-06-16 | E-GEOD-8146 | biostudies-arrayexpress
2018-06-02 | GSE111578 | GEO