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Dietary oleic acid drives obesogenic adipogenesis via modulation of LXR⍺ signaling

ABSTRACT: Dietary oleic acid drives obesogenic adipogenesis via modulation of LXR⍺ signaling

PROVIDER: PRJNA1142950 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30111056_1.fastq.gz	Fastqsanger.gz
	SRR30111056_2.fastq.gz	Fastqsanger.gz
	SRR30111057_1.fastq.gz	Fastqsanger.gz
	SRR30111057_2.fastq.gz	Fastqsanger.gz
	SRR30111058_1.fastq.gz	Fastqsanger.gz

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Dietary oleic acid drives obesogenic adipogenesis via modulation of LXR⍺ signaling

Project description:Dietary fat composition has changed substantially as the obesity epidemic has spread. Adipocyte hyperplasia is a major mechanism of fat mass expansion in obesity, but how dietary fats contribute to obesogenic adipocyte hyperplasia is unknown. Here we employed various dietary strategies, including an unbiased dietary screen, to determine the effect of dietary fat composition on adipocyte hyperplasia in mice. We identified oleic acid (OA) as the only dietary fatty acid that induces adipogenesis and obesogenic hyperplasia at physiologic levels. OA induced differentiation via AKT2 signaling, a hallmark of obesogenic hyperplasia. We also demonstrate that reduction of LXR signaling in APCs is necessary for OA-stimulated adipogenesis. Furthermore, blocking LXRa phosphorylation at S196 results in APC hyperproliferation upon HFD feeding, suggesting that LXRa phosphorylation inhibits HFD-stimulated proliferation. As OA is associated with numerous health effects, our findings that OA is a unique physiologic metabolic regulator underscores the importance of understanding the mechanisms by which OA effects metabolic health.

2025-03-14 | GSE273735 | GEO

Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRasignaling

Project description:Dietary fat composition has changed substantially as the obesity epidemic has spread. Adipocyte hyperplasia is a major mechanism of fat mass expansion in obesity, but how dietary fats contribute to obesogenic adipocyte hyperplasia is unknown. Here we employed various dietary strategies, including an unbiased dietary screen, to determine the effect of dietary fat composition on adipocyte hyperplasia in mice. We identified oleic acid (OA) as the only dietary fatty acid that induces adipogenesis and obesogenic hyperplasia at physiologic levels. OA induced differentiation via AKT2 signaling, a hallmark of obesogenic hyperplasia. We also demonstrate that reduction of LXR signaling in APCs is necessary for OA-stimulated adipogenesis. Furthermore, blocking LXRaphosphorylation at S196 results in APC hyperproliferation upon HFD feeding, suggesting that LXRaphosphorylation inhibits HFD-stimulated proliferation. As OA is associated with numerous health effects, our findings that OA is a unique physiologic metabolic regulator underscores the importance of understanding the mechanisms by which OA effects metabolic health.

2025-03-16 | GSE273569 | GEO

Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRasignaling

Project description:Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRasignaling

| PRJNA1142435 | ENA

Adipose tissue nutrigenomic study in Iberian pigs with dietary intervention of oleic acid supplementation

Project description:We studied the influence of the oleic acid content of the diet on adipose tissue transcriptome. Iberian pigs were fed a standard (C) or a high oleic sunflower oil enriched (HO) diet. Transcriptome analyses were performed in adipose tissue samples (inner layer) obtained at slaughter (110 kg live weight) employing the Affymetrix porcine GeneChip. Normalized and filtered microarray expression data (background corrected and base-2 logarithmic-transformed) were analyzed through Bayesian inference using the GEAMM v.1.6 program. Statistically significant expression differences (FDR<0.10) between C and HO groups were observed for a total of ten probes corresponding to nine different known genes. Six genes were overexpressed in the HO group and three were overexpressed in the C group. Expression differences between groups ranged from 1.38 to 2.75-fold. The two most significantly DE genes were related with immune defense (TCRB and GPR183) and others were related with nutrient metabolism as glicerolipid metabolism (GK), phospholipid and sphingolipid metabolism (PPM1L), carbohydrate metabolism (FBP2) aminoacid metabolism and energy homeostasis (PRSS35 and CKB) and gene expression regulation and adipogenesis (RXRG). 15 Iberian castrated male pigs were adscribed to one of two experimental groups at 28 kg live weight (7 animals in Control group and 8 animals in High Oleic group). Nutritional treatment was maintained until sacrifice of the animals at 110 kg of live weight. At the sacrifice, backfat adipose tissue was sampled from each animal at the level of the last rib.

2013-06-14 | E-GEOD-47941 | biostudies-arrayexpress

Adipose tissue nutrigenomic study in Iberian pigs with dietary intervention of oleic acid supplementation

2013-06-14 | GSE47941 | GEO

Brassica napus high oleic acid vs. low oleic acid

Project description:Compared to ordinary rapeseed, high-oleic acid rapeseed has higher levels of monounsaturated fatty acids and lower levels of saturated fatty acid and polyunsaturated fatty acids, and thus is of high nutritional and health value. In addition, high-oleic acid rapeseed oil imparts cardiovascular protective effects. Based on these properties, high-oleic acid oil crops have been extensively investigated and cultivated. In this study, we employed a microarray analysis with high oleic acid line and low oleic acid line from the developing seeds (27 days after flowering) of Brassica napus.

2018-09-20 | GSE120223 | GEO

Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide mediate signaling in plant defense.

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Brassica napus high oleic acid vs. low oleic acid

Project description:Brassica napus high oleic acid vs. low oleic acid

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Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide mediate signaling in plant defense.

Project description:Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide- mediate signaling in plant defense. Nitric Oxide, Oleic acid, Salicylic acid, Arabidopsis, Defense Wild-type Col-0, mutant genotypes ssi2, ssi2 act1 and ssi2 sid2 with three biological replicates were analyzed (one array each)

2012-07-31 | E-GEOD-36797 | biostudies-arrayexpress

Androgen deprivation in PTEN/LXR -/- mice

Project description:The project is based on the transcriptomic analysis from 8 groups of animal samples : Wild Type Sham Wild Type Castrated LXR-/- Sham LXR-/- Castrated PTEN-/- Sham PTEN-/- Castrated PTEN-/-LXR-/- Sham PTEN-/-LXR-/- Castrated.

2020-07-31 | GSE134137 | GEO

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