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Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

ABSTRACT: Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

PROVIDER: PRJNA1148035 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30231963_1.fastq.gz	Fastqsanger.gz
	SRR30231963_2.fastq.gz	Fastqsanger.gz
	SRR30231964_1.fastq.gz	Fastqsanger.gz
	SRR30231964_2.fastq.gz	Fastqsanger.gz
	SRR30231965_1.fastq.gz	Fastqsanger.gz

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Multiscale Drug Screening for Cardiac Fibrosis Identifies MD2 as a Therapeutic Target

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Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target

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Multiscale Drug Screening for Cardiac Fibrosis Identifies MD2 as a Therapeutic Target

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Gene Signature-guided Drug Screening Identified Narciclasine as a Potential Therapeutic Drug for Renal Interstitial Fibrosis

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Nesterenkonia ebinurensis strain:MD2

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Transcription profiling of rice plants under the Md2 (pF2.5) condition in shoots

Project description:In this series of experiments, we wanted to study the transcriptional responses of plants to different levels of water limitation. For mild drought stress, we controlled water potential (a scientific concept for dryness of soil) by using an automated watering system. This system adds water to soil based on the pF values reported by a pF sensor in soil. pF is a classical and widely used index of water potential that was first defined by Schofield (1935). For severe stress conditions, we withheld watering or even dried plants on a lab bench. Here, the transcriptional profiles were compared between well-watered and Md2-treated rice seedling shoots.<br>Md2 (Mild drought level 2): We designated Md2 as a term that means the level of drought severity corresponding to pF2.5, which is equal to a soil matric potential of -31.0 kPa. pF2.5: The value of pF shows the soil matric potential of -31.0 kPa. pF is an index that is equivalent to the effort required for plant root systems to extract water stored in soil.

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Project description:Kluyveromyces lactis strain:MD2/1 Genome sequencing

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