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ABSTRACT: Non-tuberculosis mycobacteria remodel infectious communities in cystic fibrosis associated respiratory infections.

PROVIDER: PRJNA1152493 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30398300_1.fastq.gz	Fastqsanger.gz
	SRR30398300_2.fastq.gz	Fastqsanger.gz
	SRR30398301_1.fastq.gz	Fastqsanger.gz
	SRR30398301_2.fastq.gz	Fastqsanger.gz
	SRR30398302_1.fastq.gz	Fastqsanger.gz

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Single cell spatial transcriptome and RNA-seq analysis in human lung tissues with mycobacterial infection: RNA-seq analysis

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Project description:Background: Patients with cystic fibrosis (CF) have an elevated lifetime risk of infection and disease caused by nontuberculous mycobacteria (NTM). Currently, there is no method to predict whether patients with cystic fibrosis will develop disease related to non-tuberculous mycobacteria. In non cystic fibrosis populations, several genetic susceptibility factors have been described. In this study, we examined whether patients with cystic fibrosis demonstrate a similar pattern of genetic susceptibility and explored host immune-related biomarkers predictive of NTM pulmonary disease (NTM-PD). Methods: We evaluated whole blood gene expression using bulk RNA-seq in a cohort of CF patients at the time of first isolation of NTM. Differential gene expression was compared in patients who did (n = 12) vs. did not (n= 30) develop NTM-PD following first NTM growth. Results: No differences in demographics or composition of white blood cell sample populations at the time of sample collection were identified between groups. There were no significant differences in the expression of genes previously reported to confer susceptibility to NTM-PD in non-CF populations. However, CF patients who went on to develop NTM-PD had higher expression of genes involved in the interferon ( and ), tumor necrosis factor, and IL6 STAT3 JAK pathways. Conclusion: Patients with CF who develop NTM-PD have increased expression of genes involved in innate immunity, in contrast to non-CF populations where these responses seem to be suppressed.

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