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Establishment of U2OS osteosarcoma cell line with GREM1 knockdown

ABSTRACT: Establishment of U2OS osteosarcoma cell line with GREM1 knockdown

PROVIDER: PRJNA1153503 | ENA |

REPOSITORIES: ENA

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Establishment of U2OS osteosarcoma cell line with GREM1 knockdown

Project description:To explore the downstream regulatory pathway of GREM1, we established a U2OS osteosarcoma cell line with GREM1 knockdown

2025-08-23 | GSE275890 | GEO

Gene regulation by m6A demethylase ALKBH5 in U2OS osteosarcoma

Project description:To identify target genes regulated by ALKBH5 in osteosarcoma, we silenced the expression of ALKBH5 in osteosarcoma cell line-U2OS and tested its effect on U2OS transcriptome.

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U2OS osteosarcoma cells LC-MSMS

Project description:In order to identify the targets of miR-193a-5p in osteosarcoma U2OS cell line, we used a lentivirus-mediated expression system to overexpressing miR-193a precusor, miR-193a-5p target sequence and non-target sequence, respectively, in osteosarcoma cell line U2OS. A tandem mass tag (TMT)-based quantitative proteomic strategy was employed to identify the global profile of miR-193a-5p-regulated proteins. order to identify the targets of miR-193a-5p, we used a lentivirus-mediated expression system to overexpressing miR-193a precusor, miR-193a-5p target sequence and non-target sequence, respectively, in osteosarcoma cell line U2OS. A tandem mass tag (TMT)-based quantitative proteomic strategy was employed to identify the global profile of miR-193a-5p-regulated proteins.

2021-09-08 | PXD013987 | Pride

RNA sequencing to determine gene expression changes in SQLE knockdown osteosarcoma cells

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RNA-Seq profiles of pancreatic adenocarcinoma PANC-1 and osteosarcoma U2OS cells with Pin1 knocking down

Project description:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) mediates conformational conversion of protein substrates to trigger the modulation of protein phosphorylation status. Pin1 was knockdown in the pancreatic adenocarcinoma cell PANC-1 and osteosarcoma cell U2OS. The expression profiles of them were compared to explore the key features regulated by Pin1.

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RNA-seq data U2OS human osteosarcoma cell line etoposide treated with JMY knockdown

Project description:RNA-seq data U2OS human osteosarcoma cell line etoposide treated with JMY knockdown

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Gene expression analysis of mesenchymal stem cells (MSC), osteoblasts and the U2OS (osteosarcoma) cell line

Project description:Transcriptional profiling of MSC, Osteoblasts and U2OS cells. The aim was to quantitate relative gene expression in MSC, osteoblasts and U2OS. MSC and osteoblasts were used as normal cells in this study because osteosarcoma most likely originates from MSC or osteoblasts.

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Spontaneous cell competition in U2OS human osteosarcoma cells.

Project description:The study compares the transcriptional profiles of U2OS human osteosarcoma cells and those of two single-cell derived sub-lines carrying a stably integrated H2BmCherry (U2OS-R1) or H2B-YFP (U2OS-YFP) expression cassette. U2OS-R1 and U2OS-YFP cell spontaneously undergo apoptosis upon co-culture with the parental (Wt) U2OS cell population. Furthermore, YFP cells also undergo apoptosis upon co-culture with R1 cells. This behavior is similar to the \cell competition\ phenomenon described in the Drosophila imaginal disc and the mouse epiblast (for review, see , where fast-growing \fit\ cells induce apoptosis in slow-growing, less \fit\ neighbors. The mRNA expression profiles of Wt, R1 and YFP cells cultured alone or in pairwise combinations for 48h were analyzed after cell sorting by RNA microarray hybridization using Affymetrix Human Gene ST 1.0 chips.

2015-08-01 | E-MTAB-3204 | biostudies-arrayexpress

Next Generation Sequencing of Gene expression changes in U2OS osteosarcoma cells with PML silencing

Project description:We used next generation sequencing to analyze the gene expression changes in U2OS osteosarcoma cells expressing shRNA targeting the promyelocytic leukemia (PML) gene transcripts

2017-06-13 | GSE94126 | GEO

CBX4 role in U2OS/MTX300

Project description:In our study, we found that CBX4 was critical to osteosarcoma metastasis.CBX4, also known as polycomb 2 (Pc2), belongs to the CBX protein family, including CBX2, 4, 6, 7, and 8, which has been shown to participate in the polycomb repressive complex 1 (PRC1) and characterized as a transcriptional repressor. To identify the downstream target genes of CBX4 in osteosarcoma, we conducted the RNA-seq analysis of CBX4 overexpression or knockdown in osteosarcoma cell line U2OS/MTX300.

2020-02-04 | GSE140763 | GEO

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