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Surface CD69-negative bone-marrow resident human memory T cells [ESR transcription]

ABSTRACT: Surface CD69-negative bone-marrow resident human memory T cells [ESR transcription]

PROVIDER: PRJNA1166208 | ENA |

REPOSITORIES: ENA

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Surface CD69-negative bone-marrow resident human memory T cells [ESR transcription]

Project description:Across tissues, tissue-resident memory T cells have been defined as cells which express CD69 in their cell surface, but not S1PR1, the receptor for the tissue-egress signal sphingosin-1-phosphate (S1P). It is less clear whether CD69-negative memory T cells are also tissue-resident. Here, we compare transcriptomes and T cell receptor repertoires of individual CD4 and CD8 memory T cells from paired blood and bone marrow of three human donors. CD69- memory T cells of blood and bone marrow share transcriptionally defined clusters, as defined by signature genes reflecting their imprinting during activation. However, cells of related clusters of blood and bone marrow have distinct TCR repertoires, suggesting that they represent distinct compartments of memory, and that the CD69- memory T cells are residents of the bone marrow. Interestingly, the surface CD69- memory T cells of bone marrow do transcribe the CD69 gene, and they express S1PR1, suggesting that they are blindfolded for S1P by dimerization and internalization of CD69 and S1PR1, maintaining them in the tissue.

2025-05-21 | GSE278283 | GEO

Surface CD69-negative bone-marrow resident human memory T cells [ESR TCR]

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Surface CD69-negative bone-marrow resident human memory T cells [ESR TCR]

Project description:Surface CD69-negative bone-marrow resident human memory T cells [ESR TCR]

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CD69+ memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes

Project description:To understand tissue resident features of memory CD4+ and CD8+ T lymphocytes of the bone marrow and/or spleen according to expressing or not the tissue retention marker CD69, we performed whole transcriptome profiling of ex vivo antigen-specific CD69+ and CD69- memory CD4+ T cells isolated from bone marrow and spleen, and ex vivo CD69+ and CD69- memory CD8+ T cells isolated from bone marrow.

2019-02-11 | GSE124796 | GEO

Whole-transcriptome profiling of murine steady state CD69+ and CD69- memory CD8+ T cells from the bone marrow [expression microarray]

Project description:To understand the tissue-resident features of memory CD8+ T cell subpopulations isolated from the bone marrow according to the tissue retention marker CD69, we compared the global gene expression of ex vivo isolated CD69+ and CD69- bone marrow memory CD8+ T cells.

2019-02-11 | GSE124795 | GEO

Kidney-resident CD8 T cells downregulate IL-18R during maturation

Project description:Using the expression of IL-18 receptor (CD218) as a surface marker, CD69+ kidney-resident CD8 T cells can be separated into two subsets. Transcriptional analysis suggests that IL-18R low subset represents the mature tissue-resident T cells

2020-03-01 | GSE111801 | GEO

CD69-dependent gene expression in activated CD4 T cells from the spleen of Mus musculus

Project description:CD69 is a transmembrane protein expressed on the surface of activated leukocyte. The ligand for CD69 and the intracellular signaling pathway of this molecule are yet unknown. It is widely used as a marker of activated lymphocyte, but its function in immune system is not known. We used micro-array to define genes whose expression is regulated by activation antigene CD69. CD4 T cells were isolated from the spleen of wt B6 and CD69-deficient B6 mice and in vitro activated with anti-CD3/anti-CD28 coated beads. On one groupe of wt B6 cells, CD69 was activated using a anti-CD69 and secoundary antibody. RNA extraction and hybridization on Affymetrix microarrays was performed for wt B6, CD69-activated wt B6 and CD69-deficient B6 CD4 T cells.

2011-12-29 | E-GEOD-27706 | biostudies-arrayexpress

CD69-dependent gene expression in activated CD4 T cells from the spleen of Mus musculus

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Clostridioides difficile CD69

Project description:Clostridioides difficile CD69 Genome sequencing and assembly

| PRJNA85721 | ENA

CD69+ memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes

Project description:CD69+ memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes

| PRJNA513497 | ENA

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