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Surface CD69-negative bone-marrow resident human memory T cells [ESR TCR]

ABSTRACT: Surface CD69-negative bone-marrow resident human memory T cells [ESR TCR]

PROVIDER: PRJNA1166216 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30820121_1.fastq.gz	Fastqsanger.gz
	SRR30820121_2.fastq.gz	Fastqsanger.gz
	SRR30820122_1.fastq.gz	Fastqsanger.gz
	SRR30820122_2.fastq.gz	Fastqsanger.gz
	SRR30820123_1.fastq.gz	Fastqsanger.gz

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Surface CD69-negative bone-marrow resident human memory T cells [ESR TCR]

Project description:Across tissues, tissue-resident memory T cells have been defined as cells which express CD69 in their cell surface, but not S1PR1, the receptor for the tissue-egress signal sphingosin-1-phosphate (S1P). It is less clear whether CD69-negative memory T cells are also tissue-resident. Here, we compare transcriptomes and T cell receptor repertoires of individual CD4 and CD8 memory T cells from paired blood and bone marrow of three human donors. CD69- memory T cells of blood and bone marrow share transcriptionally defined clusters, as defined by signature genes reflecting their imprinting during activation. However, cells of related clusters of blood and bone marrow have distinct TCR repertoires, suggesting that they represent distinct compartments of memory, and that the CD69- memory T cells are residents of the bone marrow. Interestingly, the surface CD69- memory T cells of bone marrow do transcribe the CD69 gene, and they express S1PR1, suggesting that they are blindfolded for S1P by dimerization and internalization of CD69 and S1PR1, maintaining them in the tissue.

2025-05-21 | GSE278281 | GEO

Surface CD69-negative bone-marrow resident human memory T cells [ESR transcription]

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Surface CD69-negative bone-marrow resident human memory T cells [ESR transcription]

Project description:Surface CD69-negative bone-marrow resident human memory T cells [ESR transcription]

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CD69+ memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes

Project description:To understand tissue resident features of memory CD4+ and CD8+ T lymphocytes of the bone marrow and/or spleen according to expressing or not the tissue retention marker CD69, we performed whole transcriptome profiling of ex vivo antigen-specific CD69+ and CD69- memory CD4+ T cells isolated from bone marrow and spleen, and ex vivo CD69+ and CD69- memory CD8+ T cells isolated from bone marrow.

2019-02-11 | GSE124796 | GEO

Whole-transcriptome profiling of murine steady state CD69+ and CD69- memory CD8+ T cells from the bone marrow [expression microarray]

Project description:To understand the tissue-resident features of memory CD8+ T cell subpopulations isolated from the bone marrow according to the tissue retention marker CD69, we compared the global gene expression of ex vivo isolated CD69+ and CD69- bone marrow memory CD8+ T cells.

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Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

Project description:The aim of the dataset was to study on a genome-wide level the impact of Lat deficiency on gene expression in resting and activated CD4+ T cells Lat+ and Lat? CD4+ T cells were isolated from lymph nodes and spleen of Latfl-dtr Tmat-Cre mice using a Dynabeads untouched mouse CD4 cells kit (Life Technology) and further purified by cell sorting. Lat+ CD4+ T cells were defined as: CD5+, hDTR+, CD8?, TCR???, CD25?, CD69?, CD62L+, lineage (CD11c, CD11b, CD19, CD45R, CD161)? and Lat? CD4+ Tcells were defined as: CD5+, hDTR?, CD8?, TCR???, CD25?, CD69?, CD62L+, lineage (CD11c, CD11b, CD19, CD45R, CD161)?. Sorted Lat+ or Lat? CD4+ T cells were then kept in vitro for 4 hours without stimulation or activated for 4 hours using anti-CD3 antibody and anti-CD28 antibody. Cell samples corresponding to three biological replicates were analyzed and gene expression profiles were obtained from total RNA.

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Cd69

Project description:Rattus norvegicus Cd69, Cd69 molecule [Source:RGD Symbol;Acc:61318], is differentially expressed in 20 experiment(s);

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Cd69

Project description:Rattus norvegicus Cd69, Cd69 molecule [Source:RGD Symbol;Acc:61318], is expressed in 3 baseline experiment(s);

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Project description:Sus scrofa CD69, CD69 molecule [Source:VGNC Symbol;Acc:VGNC:103223], is differentially expressed in 1 experiment(s);

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