Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Microbial diversity in mouse gut affected by capsaicin intervention

PROVIDER: PRJNA1171754 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30951145_1.fastq.gz	Fastqsanger.gz
	SRR30951145_2.fastq.gz	Fastqsanger.gz
	SRR30951146_1.fastq.gz	Fastqsanger.gz
	SRR30951146_2.fastq.gz	Fastqsanger.gz
	SRR30951147_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 64

Similar Datasets

Morphine treatment induces distinct changes in the gut microbiome at day 3 post treatment

Project description:Opioids such as morphine have many beneficial properties as analgesics, however, opioids may induce multiple adverse gastrointestinal symptoms. We have recently demonstrated that morphine treatment results in significant disruption in gut barrier function leading to increased translocation of gut commensal bacteria. However, it is unclear how opioids modulate the gut homeostasis. By using a mouse model of morphine treatment, we studied effects of morphine treatment on gut microbiome. We characterized phylogenetic profiles of gut microbes, and found a significant shift in the gut microbiome and increase of pathogenic bacteria following morphine treatment when compared to placebo. In the present study, wild type mice (C57BL/6J) were implanted with placebo, morphine pellets subcutaneously. Fecal matter were taken for bacterial 16s rDNA sequencing analysis at day 3 post treatment. A scatter plot based on an unweighted UniFrac distance matrics obtained from the sequences at OTU level with 97% similarity showed a distinct clustering of the community composition between the morphine and placebo treated groups. By using the chao1 index to evaluate alpha diversity (that is diversity within a group) and using unweighted UniFrac distance to evaluate beta diversity (that is diversity between groups, comparing microbial community based on compositional structures), we found that morphine treatment results in a significant decrease in alpha diversity and shift in fecal microbiome at day 3 post treatment compared to placebo treatment. Taxonomical analysis showed that morphine treatment results in a significant increase of potential pathogenic bacteria. Our study shed light on effects of morphine on the gut microbiome, and its role in the gut homeostasis.

2018-04-16 | E-MTAB-5546 | biostudies-arrayexpress

Project description:Gut microbiota of mice under capsaicin intervention

| PRJNA555403 | ENA

Project description:Microbial diversity in mouse gut affected by Fructooligosaccharides (FOS)

| PRJNA1198297 | ENA

Project description:Microbial diversity in mouse gut affected by overcrowding stress

| PRJNA1122309 | ENA

Host/microbial cross-talk in the gut: In-depth investigation of the symbiotic effects of Roseburia hominis

Project description:Here, we report analysis of both the bacterial and host transcriptome as affected by colonization of R. hominis in the mouse gut. Microbial genes required for colonization and adaptation in the murine gut, as well as host genes responding to colonization by this bacterial species, were uncovered.

2016-02-05 | GSE25544 | GEO

Project description:microbial diversity in mouse gut affected by dietary potassium sorbate

| PRJNA1063585 | ENA

Project description:Microbial diversity in mouse gut affected by 1-kestose supplements

| PRJNA1234880 | ENA

Project description:Studies of dietary capsaicin microbial diversity on depressed mice gut

| PRJNA678526 | ENA

Project description:Microbial diversity in the mouse gut affected by high fat diet

| PRJNA1149506 | ENA

Project description:the gut microbial diversity after polysaccharides intervention

| PRJNA1026524 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data