Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation [snRNA-seq]

ABSTRACT: A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation [snRNA-seq]

PROVIDER: PRJNA1179423 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31154100_1.fastq.gz	Fastqsanger.gz
	SRR31154100_2.fastq.gz	Fastqsanger.gz
	SRR31154101_1.fastq.gz	Fastqsanger.gz
	SRR31154101_2.fastq.gz	Fastqsanger.gz
	SRR31154102_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 152

Similar Datasets

A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation [Spatial Transcriptomics]

Project description:A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation [Spatial Transcriptomics]

| PRJNA1179426 | ENA

A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation [snRNA-seq]

Project description:The human brain undergoes protracted post-natal maturation, guided by dynamic changes in gene expression. Most studies exploring these processes have used bulk tissue analyses, which mask cell type-specific gene expression dynamics. Here, using single nucleus (sn)RNA-seq on temporal lobe tissue, including samples of African ancestry, we build a joint paediatric and adult atlas of 75 cell subtypes, which we verify with spatial transcriptomics. We explore the differences between paediatric and adult cell subtypes, revealing the genes and pathways that change during brain maturation. Our results highlight excitatory neuron subtypes, including the LTK and FREM subtypes, that show elevated expression of genes associated with cognition and synaptic plasticity in paediatric tissue. The resources we present here improve our understanding of the brain during its development and contribute to global efforts to build an inclusive brain cell map.

2024-11-20 | GSE280569 | GEO

A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation.

Project description:The human brain undergoes protracted postnatal maturation, guided by dynamic changes in gene expression. Most studies exploring these processes have used bulk tissue analyses, which mask cell-type-specific gene expression dynamics. Here, using single-nucleus RNA sequencing on temporal lobe tissue, including samples of African ancestry, we build a joint pediatric and adult atlas of 75 cell subtypes, which we verify with spatial transcriptomics. We explore the differences between pediatric and adult cell subtypes, revealing the genes and pathways that change during brain maturation. Our results highlight excitatory neuron subtypes, including the LTK and FREM subtypes, that show elevated expression of genes associated with cognition and synaptic plasticity in pediatric tissue. The resources we present here improve our understanding of the brain during its development and contribute to global efforts to build an inclusive brain cell map.

| S-EPMC11631765 | biostudies-literature

TSC SEGA Atlas [snRNA-seq]

Project description:TSC SEGA Atlas [snRNA-seq]

| PRJNA1232711 | ENA

A temporal cortex cell atlas highlights gene expression dynamics during human brain maturation [Spatial Transcriptomics]

2024-11-20 | GSE280570 | GEO

snRNA-seq on hippocampus (Hip) and prefrontal lobe cortex (PFC) tissue in mice

Project description:We performed high-throughput snRNA-seq on hippocampus (Hip) and prefrontal lobe cortex (PFC) tissue in mice (Mus musculus) to identify cell-type specific differentially expressed genes. Mice were divided into GF, SPF and CGF group.

2023-03-15 | GSE202704 | GEO

Opposing transcriptional circuits governing skeletal muscle development and maturation revealed at single nuclear resolution [snRNA-seq]

Project description:To explore the mechanistic basis of the different phases of pre- and postnatal muscle development and the contraction-dependent control of muscle gene expression , we generated a multi-omics single nucleus RNAseq (snRNA-seq) and single nucleus ATAC-seq (snATAC-seq) atlas of normal muscle and paralyzed muscle from mice lacking Cacna1s.

2023-05-31 | GSE211543 | GEO

Temporal Cortex Alzheimer's Disease

Project description:Ion channel splice array data from temporal cortex brain tissue samples collected from Alzheimer's disease patients. Temporal cortex (Alzheimer's disease affected brain tissue structure) and cerebellum (Alzheimer's disease unaffected brain tissue structure) samples from control subjects were compared to temporal cortex and cerebellum of patients with Alzheimer's disease.

2010-06-11 | E-GEOD-6775 | biostudies-arrayexpress

Temporal Cortex Control (mesial temporal lobe epilepsy control)

Project description:Ion channel splice array data from temporal cortex brain tissue samples collected from control subjects (no mesial temporal lobe epilepsy). Keywords: disease associated splicing changes Temporal cortex samples from control subjects were compared to temporal neocortex of patients with mesial temporal lobe epilepsy

2007-01-23 | E-GEOD-6771 | biostudies-arrayexpress

Melanoma Brain Metastasis Atlas [single-cell/nuclei RNA-sequencing (sc/snRNA-seq)]

Project description:Melanoma Brain Metastasis Atlas [single-cell/nuclei RNA-sequencing (sc/snRNA-seq)]

| PRJNA823695 | ENA