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The RNA-binding protein TRIM71 times auditory sensory development

ABSTRACT: The RNA-binding protein TRIM71 times auditory sensory development

PROVIDER: PRJNA1183852 | ENA |

REPOSITORIES: ENA

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The RNA-binding protein TRIM71 times auditory sensory development

Project description:Utilizing conditional Trim71 knockout mice, we find that Trim71 deletion during early otic development causes hearing loss and induces premature cell cycle exit and differentiation of hair cell progenitors. Transcriptomic and genetic experiments reveal that TRIM71 maintains hair cell-progenitors proliferative and undifferentiated through repressing TGF-β-type signaling.

2025-06-21 | GSE281437 | GEO

Runx1 Controls Auditory Sensory Neuron Diversity (iCKO)

Project description:As the primary sensory neurons of the auditory system, Type I spiral ganglion neurons (SGNs) encode sound stimulus properties critical for the formation of auditory percept in higher brain areas. Their functional heterogeneity is thought to contribute to our ability to hear a wide range of sound intensities and against background noise, but how SGN diversity arises during development is poorly understood. Here we studied the role of the transcription factor Runx1 in establishing SGN heterogeneity in the mouse cochlea by single cell RNA-sequencing.

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Runx1 Controls Auditory Sensory Neuron Diversity (CKO)

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Runx1 Controls Auditory Sensory Neuron Diversity (iCKO)

Project description:Runx1 Controls Auditory Sensory Neuron Diversity (iCKO)

| PRJNA864782 | ENA

Runx1 Controls Auditory Sensory Neuron Diversity (CKO)

Project description:Runx1 Controls Auditory Sensory Neuron Diversity (CKO)

| PRJNA864783 | ENA

mRNA sequencing of Trim71 conditional ("WT") and Trim71 KO mES cells

Project description:We report that Trim71 mutation does not lead to significant changes within the core regulatory network of mES cells, however, there is an upregulation of specific genes involved in neural differentiation. We thus conclude that Trim71 KO mES cells are poised for differentiation.

2015-10-01 | GSE62398 | GEO

Studies on Trim71 in mouse embryonic stem cells

Project description:We studies on Trim71 regulates mouse embryonic stem cells by identifying the transcriptome-wide RNA targets of Trim71. Moreover, through inhibiting specific Trim71:mRNA interactions, we determined how Trim71 modulate miRNA activity in mouse embryonis cell cells

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Studies on a hydrocephalus-causing mutation on Trim71

Project description:We studies on how a hydrocephalus-causing mutation (R783H) on Trim71 alters Trim71's substrate mRNA binding

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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1

Project description:We demonstrate that global effects of TRIM71 on the cellular transcriptome of mouse embryonic stem cells (mESCs) are largely attributable to its RNA binding activity, and map the transcriptome-wide targets of wild-type TRIM71, NHL domain mutant TRIM71, and RING domain mutant TRIM71.

2019-08-01 | GSE130248 | GEO

Studies on the R595H hydrocephalus-associated mutation on Trim71

Project description:We studies on how a hydrocephalus-associated mutation (R595H) on Trim71 alters Trim71's substrate mRNA binding

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