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ABSTRACT: Gene expression changes in human gastric adenocarcinoma cells (AGS) after overexpression of LGALS9B

PROVIDER: PRJNA1188737 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31419117.fastq.gz	Fastqsanger.gz
	SRR31419118.fastq.gz	Fastqsanger.gz
	SRR31419119.fastq.gz	Fastqsanger.gz
	SRR31419120.fastq.gz	Fastqsanger.gz
	SRR31419121.fastq.gz	Fastqsanger.gz

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DIA-Based Quantitative Proteomics Analysis of Human Gastric Cancer Cells

Project description:This study investigates the proteomic landscape of AGS gastric cancer cells with stable overexpression of the VASN gene. Utilizing DIA-based quantitative proteomics, we examined protein expression changes in VASN-overexpressing AGS cells compared to their negative control (NC) counterparts. The resulting dataset offers valuable insights into the molecular mechanisms underlying VASN overexpression in gastric cancer.

2026-06-29 | PXD058610 | Pride

Project description:Gene expression changes in human gastric adenocarcinoma cells (AGS) after knockdown of LGALS9B

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Project description:This study investigates transcriptomic changes associated with CDO1 overexpression in human AGS gastric cancer cells. Poly(A)-selected mRNA libraries from CDO1-overexpressing AGS cells and corresponding control cells were sequenced using paired-end 150-bp reads on the DNBSEQ-T7 platform to identify differentially expressed genes and biological pathways regulated by CDO1 overexpression in gastric cancer cells.

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TNFα secreted from macrophages increases expression of prometastatic integrin αV in gastric cancer

Project description:We performed RNA-Seq to confirm the changes in expression of genes in the relevant pathway in human gastric cancer cells (AGS cells) and AGS cells cocultured with macrophages (RAW264.7 cells). In the gene ontology enrichment analysis of the 160 genes that were increased in AGS cells cocultured with RAW264.7 cells, pathways related to immune response, cell adhesion, and cytokine response were enriched.

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Comprehensive analysis of the immune implication of NOTCH1 gene in stomach adenocarcinoma

Project description:In order to better understand the relationship between NOTCH1 gene and immunity in gastric adenocarcinoma cells, we performed the silent interference of NOTCH1 gene on three gastric adenocarcinoma cell lines AGS, MKN-45 and MGC-803. We extracted the total RNA from the interfered and untreated blank control cells, and performed lncRNA library construction and sequencing. The results of bioinformatics analysis showed that the silencing of NOTCH1 gene in gastric adenocarcinoma cells activated several immune-related signal transduction pathways, including T cell receptors, chemokines, JAK-STAT, Toll-like receptors, ECM receptors and other signals. Conduction pathway. These results confirm that NOTCH1 may down-regulate the immune response of gastric adenocarcinoma.

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mRNA profiling of AGS Gastric Cancer cell line treated with the Homeopathy formulation, Ornithogalum

Project description:Ornithogalum is one of the therapeutic formulation used in homeopathic treatments. It is specifically used in the treatment for gastric and duodenal ulcerations. Towards understanding the anticancer mechanism, we investigated the genome-wide mRNA changes upon treating AGS Gastric Cancer cells with Ornithogalum. We observed that totally 707 genes were significantly regulated upon Ornithogalum Treatment, among them 246 genes were upregulated and 461 genes were downregulated. The results provide insight into molecular implication and gene level expression of AGS upon treatment with Ornithogalum. Total RNA was isolated from AGS gastric cancer cells treated with 0.01% of ornithogalum and ethanol control and profiled using Affymetrix Human Gene 1.0 ST Array (HuGene-1_0-st).

2014-04-01 | E-GEOD-54658 | biostudies-arrayexpress

Expression data of EBV-positive and EBV-negative subclones of gastric adenocarcinoma cell line AGS

Project description:Gastric cancer is one of the most common cancers worldwide. Epstein-Barr virus-associated gastric cancer accounts for approximately 10% of all gastric cancers. EBV expresses its own proteins and miRNAs (BART miRNAs) and regulates host gene expression. In this study, we examined the effect of EBV infection on host mRNA expression. Differential gene expression was analyzed between EBV-negative human gastric cancer cell line AGS and EBV-positive human gastric cancer cell line AGS-EBV.

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human gastric cancer cell AGS shTOPK LC-MSMS

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Project description:Background Mitogen-activated protein kinase 1 (MAPK1) has independent functions of phosphorylating histones as a kinase and directly binding the promoter regions of genes to regulate gene expression as a transcription factor. Previous studies identified elevated expression of MAPK1 in human gastric cancer, which is associated with its role as a kinase, facilitating gastric cancer cell migration and invasion. However, being a transcription factor, how MAPK1 binds its target genes and whether it modulated related gene expressions in gastric cancer remains unclear. Results Here, we integrated biochemical assays (protein interactions and chromatin immunoprecipitation (ChIP)), cellular analysis assays (cell proliferation and migration), RNA sequencing, ChIP sequencing, and clinical analysis to investigate the potential genomic recognition patterns of MAPK1 in a human gastric adenocarcinoma cell-line (AGS) and to uncover its regulatory effect on gastric cancer progression. We confirmed that MAPK1 promotes AGS cells invasion and migration by regulating the target genes in controversial directions, up-regulating seven target genes (KRT13, KRT6A, KRT81, MYH15, STARD4, SYTL4, and TMEM267) and down-regulating one gene (FGG). Among them, five genes (FGG, MYH15, STARD4, SYTL4, and TMEM267) were first associated with cancer procession, while the other three (KRT81, KRT6A, and KRT13) have been previously confirmed to be related to cancer metastasis and migration. Conclusion Our data showed that MAPK1 binds to the promoter regions of these target genes to control their transcription, hence encouraging AGS cell motility and invasion. Our research broadened the understanding of the regulatory roles of MAPK1, enriched the knowledge of transcription factors, and provided novel candidates for cancer therapeutics.

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Project description:Helicobacter pylori are gram-negative bacteria that colonize the human stomach and are the major etiological factor in gastric carcinoma development. The aim of this work was to evaluate changes in gene expression in gastric cells induced by H. pylori. The human gastric carcinoma-derived cell line AGS was infected with H. pylori strain 60190 (ATCC 49503) for 24 hours. RNA was extracted from three independent experiments.

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