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DNA Methylation Profiling at Base-Pair Resolution Reveals Unique Epigenetic Features of Early-Onset Colorectal Cancer in Underrepresented Populations

ABSTRACT: DNA Methylation Profiling at Base-Pair Resolution Reveals Unique Epigenetic Features of Early-Onset Colorectal Cancer in Underrepresented Populations

PROVIDER: PRJNA1198593 | ENA |

REPOSITORIES: ENA

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			Action	DRS
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	SRR31722584_1.fastq.gz	Fastqsanger.gz
	SRR31722584_2.fastq.gz	Fastqsanger.gz
	SRR31722585_1.fastq.gz	Fastqsanger.gz
	SRR31722585_2.fastq.gz	Fastqsanger.gz

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DNA Methylation Profiling at Base-Pair Resolution Reveals Unique Epigenetic Features of Early-Onset Colorectal Cancer in Underrepresented Populations

Project description:Background. The incidence of early-onset colorectal cancer (EOCRC) has been rising at an alarming rate in the United States, and EOCRC disproportionately affects racial/ethnic minorities. Here, we construct comprehensive profiles of EOCRC DNA methylomes at base-pair resolution for a cohort of Hispanic and African American patients. Results. We show the epigenetic landscape of these EOCRC patients differs from that of late-onset colorectal cancer (LOCRC) patients, and methylation canyons in EOCRC tumor tissue preferentially overlapped genes in cancer-related pathways. Furthermore, we identify epigenetic alterations in metabolic genes that are specific to our racial/ethnic minority EOCRC cohort but not Caucasian patients from TCGA. Top genes differentially methylated between these cohorts included the obesity-protective MFAP2 gene as well as cancer risk susceptibility genes APOL3 and RNASEL. Conclusions. In this study, we provide to the scientific community high-resolution DNA methylomes for a cohort of EOCRC patients from underrepresented populations. Our exploratory findings in this cohort highlight epigenetic mechanisms underlying the pathogenesis of EOCRC and nominate novel biomarkers for EOCRC in underrepresented populations.

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