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Parasite and vector circadian clocks mediate efficient malaria transmission

ABSTRACT: Parasite and vector circadian clocks mediate efficient malaria transmission

PROVIDER: PRJNA1198994 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR31738523.fastq.gz	Fastqsanger.gz
	SRR31738524.fastq.gz	Fastqsanger.gz
	SRR31738525.fastq.gz	Fastqsanger.gz
	SRR31738526.fastq.gz	Fastqsanger.gz

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Parasite and vector circadian clocks mediate efficient malaria transmission

Project description:Malaria transmission begins when Anopheles mosquitos deposit saliva and Plasmodium parasites during a bloodmeal. As Anopheles mosquitos are nocturnal, we investigated whether their salivary glands are under circadian control, anticipating bloodmeals and modulating parasite biology for host encounters. Here we show that approximately half of the mosquito salivary gland transcriptome, particularly genes essential for efficient bloodmeals such as anti-blood clotting factors, exhibits circadian expression. Furthermore, measuring hemoglobin levels, we demonstrate that mosquitos prefer to feed and ingest more blood at nighttime. Notably, we show a substantial subset of the salivary gland-resident parasite transcriptome cycling throughout the day, indicating that this stage is not transcriptionally quiescent. Among the sporozoite genes undergoing rhythmic expression are those involved in parasite motility, potentially modulating the ability to initiate infection at different times of day. Our findings suggest a circadian tripartite relationship between the vector, parasite and mammalian host that together modulate malaria transmission.

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