Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1202207 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Other | ||||
| SRR31814735_1.fastq.gz | Fastqsanger.gz | |||
| SRR31814735_2.fastq.gz | Fastqsanger.gz | |||
| SRR31814736_1.fastq.gz | Fastqsanger.gz | |||
| SRR31814736_2.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 5 of 145 |
Similar Datasets
Project description:<p>We identify a novel microbiota-driven anti-hypertensive mechanism mediated by Achyranthes bidentata (Ab) extract and gut microbe Dubosiella sp.. Using a hypertensive mouse model induced by L-NAME and a high-salt diet, we show that Ab extract significantly ameliorates hypertension and renal damage by selectively enriching Dubosiella in the gut microbiota. Metabolomics suggested that Ab significantly changed the metabolic profiles and enriched the lipid metabolism including arachidonic acid metabolism. In vitro, Ab significantly promote the biofilm formation of Dubosiella DSM103457. Further gavage experiments with Dubosiella DSM103457 confirmed its effects of alleviating hypertension and heart injury. Microbial and metabolic profiling via 16S rRNA sequencing, metagenomics and metabolomics revealed that Dubosiella DSM103457 modulates arachidonic acid metabolism, restoring critical prostaglandins and leukotrienes associated with cardiovascular homeostasis.</p>
2025-04-02 | MTBLS12017 | MetaboLights
Project description:<p>Background: Hypertension remains a significant global health challenge, with limited treatment efficacy in many patients. Emerging evidence suggests that gut microbiota plays a crucial role in blood pressure regulation. This study investigates the anti-hypertensive effects of Achyranthes bidentata (Ab) extract and its interaction with the gut microbiota, particularly focusing on the enrichment of Dubosiella sp. and its impact on arachidonic acid metabolism.</p><p>Results: Here, we identified a novel microbiota-driven anti-hypertensive mechanism mediated by the Ab extract and Dubosiella sp. Ab significantly ameliorated hypertension and kidney damage by enriching Dubosiella in hypertensive mice. Metabolomics analysis revealed that Ab enhances lipid metabolic pathways, particularly arachidonic acid metabolism. In vitro, Ab significantly promoted the biofilm formation of D. newyorkensis DSM103457. Further gavage experiments confirmed that D. newyorkensis DSM103457 alleviates hypertension, cardiac and kidney injury. Combined microbial and metabolic profiling via 16S rRNA sequencing, metagenomics and metabolomics demonstrated that D. newyorkensis DSM103457 modulates gut microbiota, arachidonic acid metabolism, restoring prostaglandins and leukotrienes essential for cardiovascular homeostasis. Notably, arachidonic acid significantly promotes D. newyorkensis DSM103457 growth, enabling rapid generation and transformation of HETEs and HODEs in vitro.</p><p>Conclusions: This study identified Ab-Dubosiella-arachidonic acid axis as a novel anti-hypertensive pathway, offering promise for the development of integrated herbal prebiotics and microbial probiotics for targeted hypertension therapy.</p>
2025-04-02 | MTBLS11993 | MetaboLights
Project description:Achyranthes bidentata cultivar:Achyranthes bidentata cultivar Number 1 Raw sequence reads
| PRJNA387694 | ENA
Project description:Achyranthes bidentata cultivar:Achyranthes bidentata cultivar Number 1 Raw sequence reads
| PRJNA564403 | ENA
Project description:Achyranthes bidentata Raw sequence reads
| PRJNA606917 | ENA
Project description:n-butanol peptide extract of Achyranthes bidentata seeds
2018-12-10 | MSV000083216 | MassIVE
Project description:Achyranthes bidentata Bl. Raw sequence reads
| PRJNA350183 | ENA
Project description:Cardiac hypertrophy is a cardiac structural remodeling and dysfunction resulting from chronic hypertension and is an independent risk factor for cardiovascular morbidity and mortality. Study have implicated the protect role of oxymatrine (OMT) on the ventricular remodeling in spontaneously hypertensive rats (SHRs). However, the underlying mechanisms of remains unclear. In this study, we investigated investigates the potential of OMT in improving myocardial hypertrophy in SHRs through integrated analysis of transcriptomics and metabolomics. The results show that OMT significantly alleviates myocardial hypertrophy in SHRs and improves heart function by reducing the myocardial enlargement and collagen deposition. Transcriptomic analysis revealed that OMT reversed the expression of 10 genes associated with linoleic acid/arachidonic acid metabolism, cytochrome P450, steroid hormone biosynthesis, and myocardial adrenergic signaling. Metabolomic analysis indicated that OMT reversed the levels of 16 metabolites related to steroid hormone biosynthesis, aldosterone synthesis and secretion, and tryptophan metabolism. Integrated analysis revealed that Integrated analysis identified Cyp2e1 and desoxycortone (also known deoxycorticosterone, DOC) as key genes and metabolites involved in the transcriptional and metabolic interactions through which OMT improves myocardial hypertrophy in SHR. In summary, our study underscores the potential molecular and metabolic mechanisms of OMT against pressure overload-induced myocardial hypertrophy and provides theoretical support for its exploration in other indications.
2025-09-26 | GSE282767 | GEO
Project description:<p>This study investigates the effect of Achyranthes bidentata polysaccharide-strontium (ABPS-Sr) chelate on tibial dyschondroplasia (TD) in broilers and its underlying mechanisms. TD is a prevalent leg disorder in commercial broilers characterized by reduced angiogenesis in the tibial growth plate (TGP), with limited effective interventions in modern poultry farming. ABPS-Sr was synthesized as a novel chelate, leveraging Achyranthes bidentata polysaccharide to target lower limb bone repair by delivering osteogenic and angiogenic strontium. In a thiram-induced TD broiler model, ABPS-Sr significantly improved growth performance and tibial bone microstructure, while promoting angiogenesis in the TGP. Mechanistically, ABPS-Sr promoted angiogenesis within the TGP by upregulating the expression of vascular endothelial growth factors and restored osteogenic differentiation by activating the ITGB1/FAK/PI3K/AKT1 signaling pathway. Additionally, ABPS-Sr regulated gut microbiota composition, restored intestinal barrier function, and corrected hepatic lipid metabolism disorders, particularly by reducing plasma glycerophospholipid (e.g., phosphatidylcholine) accumulation that exerts negative effects on bone health. Fecal microbiota transplantation experiments further confirmed that the gut microbiota is essential for mediating the bone-protective effects of ABPS-Sr. Collectively, these findings reveal that ABPS-Sr effectively alleviates TD through direct actions on bone repair and angiogenesis as well as by orchestrating recovery along the gut-liver-bone axis, which provides a promising nutritional intervention strategy for improving poultry bone health.</p>
2025-09-24 | MTBLS13038 | MetaboLights