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Mus musculus

ABSTRACT: The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation

PROVIDER: PRJNA120351 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR032476.fastq.gz	Fastqsanger.gz
	SRR032477.fastq.gz	Fastqsanger.gz
	SRR032478.fastq.gz	Fastqsanger.gz
	SRR032479.fastq.gz	Fastqsanger.gz

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The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation

Project description:This study was to elucidate the molecular mechanisms on delayed implantation in a global perspective through the combination of global microRNAs (miRNAs) and mRNA expression analysis in mouse uterus through Solexa sequencing. Examination of m/miRNA expression in mouse uterus.

2009-12-15 | E-GEOD-19473 | biostudies-arrayexpress

The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation

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Mst1-mediated phosphorylation of Nur77 is required for embryo implantation

Project description:Our results indicated that a Nur77-derived phosphorylated peptide containing the phosphorylated T366 promotes epithelium-embryo adhesion both in vitro and in vivo, RNA-seq analysis was applied in the uterus samples from delayed implantation mouse model treated with pepetide-pThr366 or saline intrauterus injection.

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Global transcriptome analysis of mouse uterus during embryo implantation by SAGE

Project description:The aim of this study was to examine differential gene expression profile in mouse uterus on day 5 of pregnancy between implantation sites and inter-implantation sites. There are 104,520 tags sequenced and acquired, 51,306 for non-implantation site, and 53,214 for implantation site. Keywords: Implantation, Uterus, Differential gene expression, Implantation sites and inter-implantation sites were isolated from the mouse uteri on day 5 of pregnancy from at least 20 mice. Implantation sites were identified by tail-vein injection of 0.1 ml of 1% Chicago blue 5 min before sample collection. SAGE analysis was used to examine differential gene expression in mouse uterus during embryo implantation.

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Project description:Murine uterus expression profile during Peri-implantation: Pre-implantation vs. Post-implantation

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Project description:Global transcriptome analysis of mouse uterus during embryo implantation by SAGE

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Transcriptional Profiling of Mouse Uterus at Pre-implantation Stage under VEGF Repression

Project description:In this study, a genetically repressed VEGF mouse model was used to analyze uterus transcriptome at G2.5 (gestation day 2.5) by Solexa/ Illumina’s digital gene expression (DGE) system. 831 uterus-specific and 2398 VEGF regulated genes were identified. Gene ontology analysis indicated that genes actively involved in uterus development were members of collagen biosynthesis, cell proliferation and cell apoptosis. Uterus-specific genes were enriched in activities of phosphatidyl inositol phosphate kinase, histone H3-K36 demethylation and protein acetylation. Among VEGF regulated genes, up-regulated genes were associated with RNA polymerase III activity while down-regulated genes were strongly associated with muscle development.Comparable numbers of antisense RNA transcripts were also identified. Expression levels of the antisense RNAs were found tightly correlated with their sense expression levels, an indication of possibly non-specific transcripts generated around the active promoters and enhancers. The antisense RNAs with exceptionally high or low expression levels and the antisense RNAs under VEGF regulation were also identified. These transcripts may be important candidates in regulation of uterus development. This study provides a global survey on genes and antisense transcripts regulated by VEGF in the pre-implantation stage. Results will contribute to the further studies of candidate genes and pathways in regulating implantation process and related diseases. Uteri mRNA profiles of G2.5 VEGF-normal (Dox+) and VEGF-repression (Dox-) were generated by Solexa/ Illumina’s digital gene expression (DGE) system.

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Gene expression profiling of constitutive activation of Smoothened in the mouse uterus

Project description:In order to gain a better understanding of Ihh action during embryo implantation, we constitutively activated Smo in the murine uterus using the PRcre mouse model (PRcre/+SmoM2+; SmoM2). Female SmoM2 mice were infertile. They exhibited normal serum progesterone levels and normal ovulation, but ova failed to be fertilized in vivo and the uterus failed to undergo the artificially induced decidual response. SmoM2 mice exhibited uterine hypertrophy. The endometrium had a reduced number of uterine glands and the endometrial stroma lost its normal morphologic characteristics. Microarray analysis of 3 month old SmoM2 uteri demonstrated a chondrocytic signature and confirmed that constitutive activation of SmoM2 increased extracellular matrix production. Thus, constitutive activation of Smo in the mouse uterus alters the extracellular matrix which interferes with early pregnancy. Keywords: two group comparison We constitutively activated Hh signaling in the uterus by the expression of a mutant SmoM2 allele. We crossed these mice to the PRcre mouse model to constitutively activate Smo in the murine uterus (PRcre/+SmoM2+; SmoM2). High density DNA microarray analysis was performed on 3 month old control and SmoM2 uteri.

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