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Effects of tire wear particles on freshwater bacterial-fungal community dynamics and subsequent elemental cycles using microcosms

ABSTRACT: Effects of tire wear particles on freshwater bacterial-fungal community dynamics and subsequent elemental cycles using microcosms Raw sequence reads

PROVIDER: PRJNA1208678 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32063700_1.fastq.gz	Fastqsanger.gz
	SRR32063700_2.fastq.gz	Fastqsanger.gz
	SRR32063701_1.fastq.gz	Fastqsanger.gz
	SRR32063701_2.fastq.gz	Fastqsanger.gz
	SRR32063702_1.fastq.gz	Fastqsanger.gz

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Tire-wear particle leachate toxicity to Americamysis bahia: analysis of sublethal and molecular effects

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Copper-enriched automotive brake wear particles perturb human alveolar cellular homeostasis

Project description:Background Airborne fine particulate matter with diameter < 2.5 μm (PM2.5), can reach the alveolar regions of the lungs, and is associated with over 4 million premature deaths per year worldwide. However, the source-specific consequences of PM2.5 exposure remain poorly understood. A major, but unregulated source is car brake wear, which exhaust emission reduction measures have not diminished.AQ1 Methods We used an interdisciplinary approach to investigate the consequences of brake-wear PM2.5 exposure upon lung alveolar cellular homeostasis using diesel exhaust PM as a comparator. This involved RNA-Seq to analyse global transcriptomic changes, metabolic analyses to investigate glycolytic reprogramming, mass spectrometry to determine PM composition, and reporter assays to provide mechanistic insight into differential effects. Results We identified brake- wear PM from copper-enriched non-asbestos organic, and ceramic brake pads as inducing the greatest oxidative stress, inflammation, and pseudohypoxic HIF activation (a pathway implicated in diseases associated with air pollution exposure, including cancer, and pulmonary fibrosis), as well as perturbation of metabolism, and metal homeostasis compared with brake wear PM from low- or semi-metallic pads, and also, importantly, diesel exhaust PM. Compositional and metal chelator analyses identified that differential effects were driven by copper. Conclusions We demonstrate here that brake-wear PM may perturb cellular homeostasis more than diesel exhaust PM. Our findings demonstrate the potential differences in effects, not only for non-exhaust vs exhaust PM, but also amongst different sources of non-exhaust PM. This has implications for our understanding of the potential health effects of road vehicle-associated PM. More broadly, our findings illustrate the importance of PM composition on potential health effects, highlighting the need for targeted legislation to protect public health.

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GNPS Data for identification of tire wear compound metabolites produced by the fungus Trametes Versicolor

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